Tyrphostin AG 490

  • Catalog number
    1570-5
  • Price
    161.17 USD
  • Size
    5 mg
  • Alternative_name
    2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide, AG 490
  • Description
    Selectively inhibits EGF receptor auto-phosphorylation (IC₅₀ = 100 µM) and selectively inhibits DNA synthesis and cell growth; induces apoptosis. A JAK2 inhibitor. Blocks growth of leukemia cells in vivo and in vitro.
  • CAS Number
    133550-30-8
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₇H₁₄N₂O₃
  • Molecular Weight
    294.31
  • Cell Permeable
    Yes
  • Purity
    ≥99%
  • Solubilities
    DMSO (100 mM) and ETOH (20 mM)
  • Handling
    Protect from light and air
  • Tag Line
    An EGFR inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24months
  • MDL Number
    MFCD00236452
  • PubChem CID
    5328779
  • SMILES
    C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
  • InChi
    InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
  • InChi Key
    TUCIOBMMDDOEMM-RIYZIHGNSA-N
  • MSDS Available
    Yes
  • Gene target
    Tyrphostin   490  
  • Short name
    Tyrphostin AG 490
  • Alternative name
    Tyrphostin AG 490
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