Tropifexor

  • Catalog number
    B2603-1
  • Price
    Please ask
  • Size
    1 mg
  • Alternative_name
    LJN 452, LJN-452, LJN452, 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid
  • Description
    Tropifexor (LJN452) is a highly potent, non-bile acid FXR (farnesoid X receptor) agonist with an EC₅₀ of 0.2 nM. Potentially useful for the treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
  • CAS Number
    1383816-29-2
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₉H₂₅F₄N₃O₅S
  • Molecular Weight
    603.59
  • Cell Permeable
    True
  • Purity
    ≥98% by HPLC
  • Solubilities
    in DMSO
  • Handling
    Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
  • Tag Line
    A farnesoid X receptor agonist
  • Storage Condition
    -20ºC
  • Shipping Condition
    Gel Pack
  • Shelf Life
    36 months
  • PubChem CID
    121418176
  • SMILES
    O=C(C1=CC(F)=C2N=C(N3[C@@]4([H])C[C@H](OCC5=C(C6CC6)ON=C5C7=CC=CC=C7OC(F)(F)F)C[C@]3([H])CC4)SC2=C1)O
  • InChi
    InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
  • InChi Key
    VYLOOGHLKSNNEK-PIIMJCKOSA-N
  • MSDS Available
    True
  • Gene target
  • Short name
    Tropifexor
  • Alternative name
    Tropifexor
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