-
Alternative_name
LJN 452, LJN-452, LJN452, 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid
-
Description
Tropifexor (LJN452) is a highly potent, non-bile acid FXR (farnesoid X receptor) agonist with an EC₅₀ of 0.2 nM. Potentially useful for the treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
-
CAS Number
1383816-29-2
-
Structure Available
Yes
-
Salt Form
No
-
Molecular Formula
C₂₉H₂₅F₄N₃O₅S
-
Molecular Weight
603.59
-
Cell Permeable
True
-
Purity
≥98% by HPLC
-
Solubilities
in DMSO
-
Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
-
Tag Line
A farnesoid X receptor agonist
-
Storage Condition
-20ºC
-
Shipping Condition
Gel Pack
-
Shelf Life
36 months
-
PubChem CID
121418176
-
-
SMILES
O=C(C1=CC(F)=C2N=C(N3[C@@]4([H])C[C@H](OCC5=C(C6CC6)ON=C5C7=CC=CC=C7OC(F)(F)F)C[C@]3([H])CC4)SC2=C1)O
-
InChi
InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
-
InChi Key
VYLOOGHLKSNNEK-PIIMJCKOSA-N
-
-
MSDS Available
True