Tasimelteon

  • Catalog number
    B2985-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    N-[[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide; Hetlioz; BMS 214778; VEC-162; MA 1; (1R-trans)-N-[[2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide
  • Description
    Tasimelteon is a potent Dual Melatonin Receptor Agonist (DMRA). It is used to treat non-24-hour sleep-wake disorder. The Ki values for binding affinity at melatonin receptors MT1 and MT2 receptor are 0.304 and 0.069 nM respectively in CHO–K1 cells. It shows greater affinity for the MT2 receptor which is believed to mediate circadian rhythm phase-shifting. It induces a potent, concentration-dependent inhibition of forskolin-stimulated cAMP accumulation in NIH-3T3 cells stably expressing human MT1 and MT2 receptors with EC₅₀ values of 0.74 nM and 0.1 nM repectively.
  • CAS Number
    609799-22-6
  • Structure Available
    True
  • Salt Form
    False
  • Molecular Formula
    C₁₅H₁₉NO₂
  • Molecular Weight
    245.32
  • Cell Permeable
    False
  • Purity
    0.95
  • Solubilities
    ~2 mg/ml in DMSO
  • Handling
    Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
  • Tag Line
    A potent Dual Melatonin Receptor Agonist (DMRA)
  • Storage Condition
    -20ºC
  • Shipping Condition
    RT
  • Shelf Life
    36months
  • MDL Number
    MFCD09033789
  • PubChem CID
    10220503
  • SMILES
    CCC(=O)NCC1CC1C2=C3CCOC3=CC=C2
  • InChi
    InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1
  • InChi Key
    PTOIAAWZLUQTIO-GXFFZTMASA-N
  • MSDS Available
    1
  • Gene target
  • Short name
    Tasimelteon
  • Alternative name
    Tasimelteon
Similar products
Filters
Contact
Chat with gentaur.com employee