SF1670
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Catalog number2774-5
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PricePlease ask
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Size5 mg
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Alternative_nameN-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
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DescriptionSF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor (IC₅₀ = 2 µM). It specifically binds to the active site of PTEN. At nanomolar concentrations it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes. Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.
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CAS Number345630-40-2
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₁₉H₁₇NO₃
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Molecular Weight307.34
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Cell PermeableY
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Purity≥98%
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SolubilitiesDMSO (~ 10 mg/ml)
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HandlingProtect from air and light
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Tag LineA selective PTEN inhibitor
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Storage Condition-20°C
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Shipping ConditionGel Pack
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Shelf Life36 months
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PubChem CID9926586
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SMILESCC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O
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InChiInChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
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InChi KeyVZQDDSYKVYARDW-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameSF1670
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Alternative nameSF1670
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