SF1670

• Catalog number
  2774-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  N-​(9,​10-​dihydro-​9,​10-​dioxo-​2-​phenanthrenyl)-​2,​2-​dimethyl-​propanamide
• Description
  SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor (IC₅₀ = 2 µM). It specifically binds to the active site of PTEN. At nanomolar concentrations it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes. Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.
• CAS Number
  345630-40-2
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₉H₁₇NO₃
• Molecular Weight
  307.34
• Cell Permeable
  Y
• Purity
  ≥98%
• Solubilities
  DMSO (~ 10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A selective PTEN inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  9926586
• PubChem CID Link
• SMILES
  CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O
• InChi
  InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
• InChi Key
  VZQDDSYKVYARDW-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SF1670  
• Short name
  SF1670
• Alternative name
  SF1670

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