Semagacestat

• Catalog number
  2430-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide ; LY450139
• Description
  A potent γ-secretase inhibitor (IC₅₀ = 10.9 nM, 12.1 nM and 12.0 nM for Aβ42, Aβ40 and Aβ38, respectively). Semagacestat has shown to reduce the rate of formation of amyloid-β in vitro and in vivo.
• CAS Number
  425386-60-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₇N₃O₄
• Molecular Weight
  361.44
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>60 mg/ml) or EtOH (>40 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A potent γ-secretase inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  9843750
• PubChem CID Link
• SMILES
  CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2CCN(C1=O)C)O
• InChi
  InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1
• InChi Key
  PKXWXXPNHIWQHW-RCBQFDQVSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Semagacestat  
• Short name
  Semagacestat
• Alternative name
  Semagacestat

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