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Alternative_name
(3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl ester; ABT-538; NSC 693184
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Description
Ritonavir is an orally bioavailable HIV-1 and HIV-2 protease inhibitor (EC₅₀ values are 0.022-0.13 and 0.16 μM, respectively). Through CYP3A4 inhibition, low doses of ritonavir can reduce the metabolism of concomitantly administered protease inhibitors, enhancing their bioavailability and efficacy.
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CAS Number
155213-67-5
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₃₇H₄₈N₆O₅S₂
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Molecular Weight
720.94
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (>10 mg/ml with slight warming)
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Handling
Protect from air and light
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Tag Line
An orally bioavailable HIV-1 and HIV-2 protease inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00927142
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PubChem CID
392622
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SMILES
CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
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InChi
InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
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InChi Key
NCDNCNXCDXHOMX-XGKFQTDJSA-N
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MSDS Available
Yes