Ripasudil hydrochloride dihydrate
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Catalog number
B2984-1
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Price
Please ask
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Size
1 mg
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Alternative_name
4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline, dihydrate, hydrochloride; K-115 Hydrochloride Dihydrate; 1H-1,4-Diazepine, 1-((4-fluoro-5-isoquinolinyl)sulfonyl)hexahydro-2-methyl-, monohydrochloride, dihydrate
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Description
Ripasudil (K-115) is a potent inhibitor of Rho kinase (ROCK), with IC₅₀ values of 19 and 51 nM for ROCK-2 and ROCK-1, respectively. Ripasudil (10 μM) induces cytoskeletal changes, including retraction, cell rounding and reduced actin bundles of cultured trabecular meshwork (TM) cells. It significantly reduces transendothelial electrical resistance (TEER) and increases FITC-dextran permeability in Schlemm’s canal endothelial (SCE) cell monolayers at a concentration of 5 μM. A 0.4% ophthalmic solution significantly lowers intraocular pressure (IOP) in rabbits and monkeys. It was the first ophthalmic solution developed for the treatment of glaucoma and ocular hypertension in Japan.
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CAS Number
887375-67-9
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Structure Available
True
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Salt Form
True
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Molecular Formula
C₁₅H₂₃ClFN₃O₄S
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Molecular Weight
395.88
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Cell Permeable
True
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Purity
0.99
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Solubilities
50 mg/ml in Water
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
A potent Rho kinase (ROCK) inhibitor
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36 months
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MDL Number
MFCD26960897
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PubChem CID
11625386
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SMILES
CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)F.O.O.Cl
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InChi
InChI=1S/C15H18FN3O2S.ClH.2H2O/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14;;;/h2,4-5,9-11,17H,3,6-8H2,1H3;1H;2*1H2/t11-;;;/m0.../s1
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InChi Key
CMDJNMACGABCKQ-XVSRHIFFSA-N
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MSDS Available
1
Product images
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