Rat Renin Inhibitor Screening Kit (Fluorometric)

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• Catalog number
  K798-100
• Price:

  757.63 USD

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• Size
  100 assays

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• Description
  Sensitive Assay to Screen Rat Renin Inhibitors, HTS
• Summary
  • Detection Method – Fluorescence (Ex/Em = 328/552 nm) • Application: - Screening potential inhibitors of rat renin - Characterize/study rat renin inhibitors
• Detection Method
  Fluorescence (Ex/Em = 328/552 nm)
• Applications
  • Screening/Characterizing/studying potential inhibitors of rat renin
• Features Benefits
  • Rapid & HTS • Reliable test for screening/studying/characterizing potential inhibitors of rat renin • Includes Inhibitor Control
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. BioVision’s Rat Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Rat Renin inhibitor, the rate of hydrolysis of the substrate is decreased or inhibited. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of rat renin inhibitors. It is also adaptable to a 384-well format.
• Data Sheet Link
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus

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• Gene target
  Renin   Inhibitor   Screening   Kit   Fluorometric  
• Short name
  Renin Inhibitor Screening Kit (Fluorometric)
• Host
  Rat
• Species
  Rat, Rats
• Alternative name
  Rat Renin suppressor detection reagent (fluorescence)
• Alternative technique
  kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

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