PKC412

• Catalog number
  2052-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4'-N-Benzoyl Staurosporine; CGP-41251; Midostaurin
• Description
  Cell-permeable. A derivative of Staurosporine (Cat. No. 1048) that inhibits a variety of serine/threonine and tyrosine kinases including protein kinase C (PKC) IC₅₀ = 50 nM), cyclic AMP-dependent protein kinase (PKA) (IC₅₀ = 2.4 µM), S6 kinase (IC₅₀ = 5.0 µM), and EGFR (IC₅₀ = 3.0 µM). PKC412 reverses the efflux function of the multidrug resistance (MDR)-1 gene product, P-glycoprotein (P-gp).
• CAS Number
  120685-11-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₅H₃₀N₄O₄
• Molecular Weight
  570.64
• Cell Permeable
  Yes
• Purity
  ≥99% by HPLC
• Solubilities
  DMSO (~ 10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A protein kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD10687105
• PubChem CID
  9829523
• PubChem CID Link
• SMILES
  CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
• InChi
  InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
• InChi Key
  BMGQWWVMWDBQGC-IIFHNQTCSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  PKC412  
• Short name
  PKC412
• Alternative name
  PKC412

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