Pan-caspase inhibitor, Q-VD(OMe)-OPh
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Catalog number
2787-1
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Price
Please ask
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Size
1 mg
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Alternative_name
(S)-methyl 5-(2,6-difluorophenoxy)-3-((S)-3-methyl-2-(quinoline-2-carboxamido)butanamido)-4-oxopentanoate
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Description
A pan-caspase inhibitor. Q-VD(OMe)-OPh is the methyl ester derivative of the pan-caspase inhibitor Q-VD-OPh (Cat. No.1170). Esterification of the aspartic acid should enhance the cell-permeability of Q-VD(OMe)-OPh.
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Structure Available
Y
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Peptide sequence
Q-Val-Asp(OMe)-Oph
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Salt Form
No
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Molecular Formula
C₂₆H₂₅F₂N₃O₆
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Molecular Weight
527.52
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Cell Permeable
Y
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Purity
≥98% by HPLC
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Solubilities
DMSO (>10 mg/ml)
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Handling
Protect from air and light
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Tag Line
A pan-casapase inhibitor
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Storage Condition
-20°C
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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SMILES
O=C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(OC)=O)C(C(C)C)NC(C2=NC3=CC=CC=C3C=C2)=O
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InChi
InChI=1S/C27H27F2N3O6/c1-15(2)24(32-26(35)20-12-11-16-7-4-5-10-19(16)30-20)27(36)31-21(13-23(34)37-3)22(33)14-38-25-17(28)8-6-9-18(25)29/h4-12,15,21,24H,13-14H2,1-3H3,(H,31,36)(H,32,35)
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InChi Key
ZZIXRXQNWVEGPY-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
GNAQ, CENPQ, H2AC20, H2AC18, SYNCRIP, H2BC21
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Short name
Pan-caspase inhibitor, Q-VD(OMe)-OPh
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Alternative name
Pan-caspase suppressor, Q-VD(OMe)-OPh
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Gene info
Gene info
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Identity
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Gene
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Long gene name
centromere protein Q
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Synonyms gene
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Synonyms gene name
- chromosome 6 open reading frame 139
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Synonyms
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GenBank acession
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Locus
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Discovery year
2003-06-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Constitutive centromere associated network
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 20
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Synonyms gene
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Synonyms gene name
- H2A histone family, member Q
- histone 2, H2ac
- histone cluster 2, H2ac
- histone cluster 2 H2A family member c
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
H2A clustered histone 18
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Synonyms gene
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Synonyms gene name
- H2A histone family, member O
- histone 2, H2aa
- histone 2, H2aa3
- histone cluster 2, H2aa3
- histone cluster 2 H2A family member a3
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-09-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
Gene info
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Identity
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Gene
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Long gene name
H2B clustered histone 21
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Synonyms gene
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Synonyms gene name
- H2B histone family, member Q
- histone 2, H2be
- histone cluster 2, H2be
- histone cluster 2 H2B family member e
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Synonyms
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GenBank acession
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Locus
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Discovery year
1998-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
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Tree numbers
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