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Alternative_name
N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide
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Description
ONO-1078 is a novel leukotriene antagonist that inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro. It also shows concentration dependent inhibition and reverses contraction of isolated human bronchus induced by LTC4 and LTD4 and antigen. ONO-1078 was 100 times more potent than FPL-55712 in inhibiting LTC4 induced contractions.
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CAS Number
103177-37-3
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₇H₂₃N₅O₄
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Molecular Weight
481.5
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (>20 mg/ml)
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Handling
Protect from air and light
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Tag Line
A novel leukotriene antagonist that inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00864631
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PubChem CID
4887
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SMILES
1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC4=C(C=C3)C(=O)C=C(O4)C5=NNN=N5
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InChi
InChI=1S/C27H23N5O4/c33-23-17-25(26-29-31-32-30-26)36-24-16-20(11-14-22(23)24)28-27(34)19-9-12-21(13-10-19)35-15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-14,16-17H,4-5,8,15H2,(H,28,34)(H,29,30,31,32)
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InChi Key
UAJUXJSXCLUTNU-UHFFFAOYSA-N
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MSDS Available
Yes
