Notch-2, mouse recombinant

  • Catalog number
    7531-25
  • Price
    Please ask
  • Size
    25 ug
  • Synonyms
    Neurogenic Locus Notch Homolog Protein 2; Notch B
  • Alternative_names
    Neurogenic Locus Notch Homolog Protein 2; Notch B
  • Description
    Protein involved in lateral inhibition in embryogenesis and multiple cellular processes through-out adulthood.
  • Recombinant
    Yes
  • Source
    CHO cells
  • Purity by SDS PAGE
    ≥95%
  • Assay
    SDS-PAGE
  • Molecular Weight
    ~87.0 kDa. The extracellular domain of mouse Notch-2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized with PBS
  • Reconstitution Instructions
    Reconstitute with sterile water to 1 mg/ml.
  • Background Information
    Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    Notch-2  
  • Gene symbol
    NOTCH2, NOTCH2NLR, NOTCH2NLA
  • Short name
    Notch-2, mouse recombinant
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Host
    mouse
  • Species
    Mouse, Mouses
  • Alternative name
    Notch-2, mouse Rec.
  • Alternative technique
    rec, murine
Gene info
  • Identity
  • Gene
  • Long gene name
    notch receptor 2
  • Synonyms gene name
    • Notch (Drosophila) homolog 2
    • Notch homolog 2 (Drosophila)
    • notch 2
  • GenBank acession
  • Locus
  • Discovery year
    1994-11-10
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Notch receptors
  • VEGA ID
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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