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Alternative_name
5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[4-[3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
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Description
Neomycin sulfate is a broad spectrum aminoglycoside antibiotic composed of a number of related neomycin compounds including neomycin A (neamine), neomycin B (framycetin), neomycin C, and a few minor compounds found in much lower quantities. Neomycin B is the most active component in neomycin followed by neomycin C and neomycin A. This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺+ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons.
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CAS Number
1405-10-3
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₃H₄₆N₆O₁₃·3H₂SO4
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Molecular Weight
908.9
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Cell Permeable
Yes
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Purity
≥90%
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Solubilities
H₂O (~50 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
Abroad spectrum aminoglycoside antibiotic
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00077833
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PubChem CID
44134844
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SMILES
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O
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InChi
InChI=1S/C23H46N6O13.3H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4)
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InChi Key
KWBUARAINLGYMG-UHFFFAOYSA-N
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MSDS Available
Yes
