MDL 28170

Alternative_name

Z-Val-Phe-CHO; Carbobenzoxy-valinyl-phenylalaninal; Calpain Inhibitor III
Description

A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation.
CAS Number

88191-84-8
Structure Available

Yes
Peptide sequence

Z-Val-Phe-CHO
Salt Form

No
Molecular Formula

C₂₂H₂₆N₂O₄
Molecular Weight

382.45
Cell Permeable

Yes
Purity

≥95% by HPLC
Solubilities

DMSO (200 mM)
Handling

Protect from air and moisture
Tag Line

A potent calpain and cathepsin B inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24months
MDL Number

MFCD00798796
PubChem CID

9907994
PubChem CID Link
SMILES

CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
InChi

InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)
InChi Key

NGBKFLTYGSREKK-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:2054
Gene

CLEC5A
Long gene name

C-type lectin domain containing 5A
Synonyms gene
- CLECSF5
Synonyms gene name
- C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5
- C-type lectin domain family 5, member A
- C-type lectin domain family 5 member A
Synonyms
- MDL-1
Locus

7q34
Discovery year

1999-10-19
Entrez gene record

23601
Pubmed identfication
- 10449773
RefSeq identity
- NM_013252
Classification
- C-type lectin domain containing
VEGA ID

OTTHUMG00000157173