K02288

• Catalog number
  B2321-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-phenol
• Description
  A potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC₅₀ = 100 nM) without affecting TGF-β signaling.
• CAS Number
  1431985-92-0
• Structure Available
  Yes
• Molecular Formula
  C₂₀H₂₀N₂O₄
• Molecular Weight
  352.38
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  >30 mg/ml (DMSO) in 0
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  Type I bone morphogenic protein (BMP) receptors inhibitors
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  46173038
• PubChem CID Link
• SMILES
  COC1=CC(=CC(=C1OC)OC)C2=C(N=CC(=C2)C3=CC(=CC=C3)O)N
• InChi
  InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
• InChi Key
  CJLMANFTWLNAKC-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  K02288  
• Short name
  K02288
• Alternative name
  K02288

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