Istradefylline

• Catalog number
  B3013-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  KW-6002; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine; 8-[2-(3,4-Dimethoxy-phenyl)-vinyl]-1,3-diethyl-7-methyl-3,7-dihydro-purine-2,6-dione; 8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
• Description
  Istradefylline is an adenosine receptor 2A (A2A) antagonist with a Ki value of 2.2 nM in a radioligand binding assay. Oral administration of Istradefylline reverses motor disability without inducing dyskinesias or hyperactivity in an MPTP-induced marmoset model of Parkinson's disease. It also decreases bradykinesia and improves attentional and working memory deficits induced by L-DOPA in an MPTP-induced macaque model of Parkinson's disease.
• CAS Number
  155270-99-8
• Structure Available
  1
• Molecular Formula
  C₂₀H₂₄N₄O₄
• Molecular Weight
  384.4
• Cell Permeable
  1
• Purity
  >95%
• Solubilities
  ~8 mg/ml in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  An adenosine receptor 2A (A2A) antagonist
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• MDL Number
  MFCD00928421
• PubChem CID
  5311037
• PubChem CID Link
• SMILES
  CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C
• InChi
  InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
• InChi Key
  IQVRBWUUXZMOPW-PKNBQFBNSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Istradefylline  
• Short name
  Istradefylline
• Alternative name
  Istradefylline

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