Imidapril hydrochloride

Alternative_name

(4S)-3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid hydrochloride, Novaloc, TA 6366, Tanapril
Description

Imidapril is a prodrug for the active metabolite imidaprilat, an angiotensin-converting enzyme (ACE) inhibitor that suppresses the conversion of angiotensin I to angiotensin II (IC₅₀ = 2.6 nM), thereby preventing vasoconstriction and decreasing aldosterone secretion by the adrenal cortex which leads to an increase in sodium excretion and subsequently increases water outflow.
CAS Number

89396-94-1
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₂₇N₃O₆ · HCl
Molecular Weight

441.91
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

H₂O (>5 mg/ml)
Handling

Protect from air and moisture
Tag Line

A potent angiotensin converting-Enzyme (ACE) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD00923828
PubChem CID

5485193
PubChem CID Link
SMILES

CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(CN(C2=O)C)C(=O)
InChi

InChI=1S/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1
InChi Key

LSLQGMMMRMDXHN-GEUPQXMHSA-N
Data Sheet Link
MSDS Available

Yes