IKK-ε Kinase Inhibitor II

  • Catalog number
    1811-1
  • Price
    161.17 USD
  • Size
    1 mg
  • Alternative_name
    5-​(5,​6-​dimethoxy-​1H-​benzimidazol-​1-​yl)-​3-​[[2-​(methylsulfonyl)phenyl]methoxy]-​2-​thiophenecarbonitrile
  • Description
    A benzimidazole analog that acts as a potent and selective inhibitor of IKK-ε kinase (IC₅₀ = 40 nM); displays >125-fold selectivity over IKK-α and IKK-β.
  • CAS Number
    862812-98-4
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₂H₁₉N₃O₅S₂
  • Molecular Weight
    469.53
  • Cell Permeable
    Yes
  • Purity
    ≥97% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    An IKK-ε kinase inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • PubChem CID
    11626927
  • SMILES
    COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C#N)OCC4=CC=CC=C4S(=O)(=O)C)OC
  • InChi
    InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)292)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3
  • InChi Key
    LDTAHRLHGHFHKP-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    IKBKE, IKBKB, CHUK, IKBKG
  • Short name
    IKK-ε Kinase Inhibitor II
  • Alternative name
    IKK-ε phosphorylation catalyst suppressor II
Gene info
  • Identity
  • Gene
  • Long gene name
    inhibitor of nuclear factor kappa B kinase subunit epsilon
  • Synonyms gene name
    • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2002-12-02
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • I kappa B kinases
    • MicroRNA protein coding host genes
  • VEGA ID
Gene info
Gene info
Gene info
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