Human CellExp™LAG3 /CD223, human recombinant
LAG3, CD223, FDC
LAG3, CD223, FDC
A protein involved in lymphocyte activation
Purity by SDS PAGE
Physical form description
Lyophilized from 0.22 um filtered PBS (pH 7.4) with 5% trehalose
Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4).
Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC. It belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. LAG3/CD223 is one of the inhibitory receptors by negatively regulating cellular proliferation, activation, and homeostasis of T cells. LAG3 can bind to HLA class-II antigens and is involved in lymphocyte activation and autoimmunity. There are now LAG3 targeted therapies both in the clinic and in preclinical development, emphasizing the broad interest in this inhibitory receptor.
Centrifuge the vial prior to opening.
For Research Use Only! Not to be used in humans
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Recombinants or rec. proteins
CellExp™LAG3 /CD223, recombinant
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
H. sapiens CellExp™lymphocyte-activation gene 3 /CD223, H. sapiens Rec.
Alternative to gene target
lymphocyte-activation gene 3, CD223, LAG3 and IDBG-14994 and ENSG00000089692 and 3902, MHC class II protein binding, Cell surfaces, Lag3 and IDBG-188462 and ENSMUSG00000030124 and 16768, BT.18959 and IDBG-640276 and ENSBTAG00000034295 and 515155
Long gene name
lymphocyte activating 3
Synonyms gene name
- lymphocyte-activation gene 3
Entrez gene record
- Immunoglobulin like domain containing
- CD molecules
Scope note:The initial culturing of cells derived directly from fresh TISSUES.
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