Human CellExp™ Frizzled-4 / FZD4 Protein, Human recombinant
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Catalog number
P1027-10
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Price
Please ask
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Size
10 ug
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Synonyms
FZD4, Frizzled-4, CD344, Fz-4, hFz4, FzE4
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Alternative_names
FZD4, Frizzled-4, CD344, Fz-4, hFz4, FzE4
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Recombinant
Yes
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Source
HEK 293 cells
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Purity by SDS PAGE
> 95%
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Assay
SDS-PAGE
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Molecular Weight
42.9 kDa
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Lyophilized from 0.22 um filtered solution in PBS pH 7.5. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
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Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.
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Background Information
Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
FZD4-DT, FZD4
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Short name
CellExp™ Frizzled-4 / FZD4 Protein, recombinant
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Humans
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Alternative name
H. sapiens CellExp™ Frizzled-4 / frizzled family receptor 4 Protein, H. sapiens Rec.
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Alternative technique
rec
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Alternative to gene target
frizzled family receptor 4, CD344 and EVR1 and FEVR and Fz-4 and Fz4 and FZD4S and FzE4 and GPCR and hFz4, FZD4 and IDBG-67034 and ENSG00000174804 and 8322, protein heterodimerization activity, Cell surfaces, Fzd4 and IDBG-198316 and ENSMUSG00000049791 and 14366, FZD4 and IDBG-641882 and ENSBTAG00000040128 and 445416
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Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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