GSK-3 Inhibitor, AR-A014418

  • Catalog number
    1953-2
  • Price
    129.59 USD
  • Size
    2 mg
  • Alternative_name
    N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
  • Description
    Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
  • CAS Number
    487021-52-3
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₂H₁₂N₄O₄S
  • Molecular Weight
    308.31
  • Cell Permeable
    Yes
  • Purity
    ≥98% by TLC
  • Solubilities
    DMSO (30 mg/ml)
  • Handling
    Protect from light and air
  • Tag Line
    A selective GSK-3 inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    48 months
  • MDL Number
    MFCD08277040
  • PubChem CID
    448014
  • SMILES
    COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
  • InChi
    InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12) 16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
  • InChi Key
    YAEMHJKFIIIULI-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    AKR1B1, PRKN, AR, EDNRA, MIR1302-3, MIR509-3, MIR7-3, PIRC12
  • Short name
    GSK-3 Inhibitor, AR-A014418
  • Alternative name
    GSK-3 suppressor, AR-A014418
Gene info
  • Identity
  • Gene
  • Long gene name
    aldo-keto reductase family 1 member B
  • Synonyms gene
  • Synonyms gene name
    • aldo-keto reductase family 1, member B1 (aldose reductase)
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1991-08-07
  • Entrez gene record
    231
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Aldo-keto reductases
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 12
  • Locus
    3
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
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