CUDC-101

Alternative_name

7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
Description

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC₅₀ values of 4.4, 2.4, and 15.7 nM, respectively. Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.
CAS Number

1012054-59-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₄H₂₆N₄O₄
Molecular Weight

434.49
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from light and air
Tag Line

A potent inhibitor of HDACs and receptor tyrosine kinases
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

48 months
MDL Number

MFCD15528940
PubChem CID

24756910
PubChem CID Link
SMILES

COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
InChi

InChI=1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20 (19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7, 11-12H2,2H3,(H,28,29)(H,25,26,27)
InChi Key

PLIVFNIUGLLCEK-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes