Caspase-6 Inhibitor Z-VEID-FMK

  • Catalog number
    1011-100
  • Price
    187.31 USD
  • Size
    100 ul
  • Alternative_name
    Z-VEID-FMK, Caspase-6 Inhibitor, VEID-FMK, VEID fluoromethylketone
  • Description
    VEID is the specific recognition sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
  • Structure Available
    No
  • Peptide sequence
    Z-Val-E(OMe)-Ile-Asp(OMe)-FMK
  • Salt Form
    No
  • Molecular Formula
    C₃₁H₄₅FN₄O₁₀
  • Molecular Weight
    652.9
  • Cell Permeable
    Yes
  • Purity
    >98% by HPLC
  • Handling
    Protect from light and moisture
  • Tag Line
    Caspase-6 inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    6-12 months
  • PubChem CID
    44135214
  • SMILES
    CCC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1
  • InChi
    InChI=1S/C31H45FN4O10/c1-7-19(4)27(30(42)34-22(23(37)16-32)15-25(39)45-6)35-28(40)21(13-14-24(38)44-5)33-29(41)26(18(2)3)36-31(43)46-17-20-11-9-8-10-12-20/h8-12,18-19,21-22,26-27H,7,13-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,40)(H,36,43)
  • InChi Key
    YPIHFMWAHMPACV-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Additional description
    Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    PSMB7, PLA2G4F, HLA-Z, ZNF276
  • Short name
    Caspase-6 Inhibitor Z-VEID-FMK
  • Alternative name
    caspase-6 suppressor Z-VEID-FMK
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
  • Tree numbers
    • E05.599.495
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