Cambinol

• Catalog number
  1653-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  5-[(2-hydroxy-5,8-dihydronaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; NSC-112546
• Description
  An inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC₅₀ = 56 µM) and SIRT2(IC₅₀ = 59 µM). Acts as an antitumor agent. Treatment of BCL6-expressing Burkitt lymphoma cells with Cambinol induces apoptosis accompanied by hyperacetylation of BCL6 and p53.
• CAS Number
  14513-15-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₆N₂O₂S
• Molecular Weight
  360.43
• Cell Permeable
  Yes
• Purity
  ≥95% by HPLC
• Solubilities
  DMSO (10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A SIRT1 inhibitor
• Storage Condition
  +4°C
• Shipping Condition
  RT
• Shelf Life
  24 months
• MDL Number
  MFCD09057543
• PubChem CID
  3246390
• PubChem CID Link
• SMILES
  C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O
• InChi
  InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7- 2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26)
• InChi Key
  RVNSQVIUFZVNAU-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Cambinol  
• Short name
  Cambinol
• Alternative name
  Cambinol

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