Calmodulin, Bovine Brain
#
-
Catalog number7291-1000
-
Price:
-
Size1 mg
-
-
SynonymsCAM, CALM
-
Alternative_namesCAM, CALM
-
DescriptionBinds to and regulates a multitude of different protein targets
-
RecombinantNo
-
SourceBovine Brain
-
Purity by SDS PAGE≥95%
-
AssaySDS-PAGE
-
Biological activity2.5 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one µmole of N-benzoyl-DL-arginine-pNA per minute at 25°C in 200 mM Tris-HCl, pH 7.8, with 20 mM CaCl2.
-
Results2.5 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one µmole of N-benzoyl-DL-arginine-pNA per minute at 25°C in 200 mM Tris-HCl, pH 7.8, with 20 mM CaCl2.
-
Unit DefinitionOne unit is defined as the amount of enzyme that hydrolyzes one µmole of N-benzoyl-DL-arginine-pNA per minute at 25°C in 200 mM Tris-HCl, pH 7.8, with 20 mM CaCl2.
-
Molecular Weight16 kDa
-
Storage Temp-20°C
-
ShippingGel Pack
-
Shelf Life12 months
-
AppearanceLyophilized
-
Physical form descriptionLyophilized in 30 mM Hepes, pH 7.4, 1 mM CaCl2 and 0.1 mM DTT.
-
Reconstitution InstructionsIn water or aqueous buffer
-
Background InformationCalmodulin (CaM) is a ubiquitous, calcium-binding protein that can bind to and regulate a multitude of different protein targets, thereby affecting many different cellular functions. CaM mediates processes such as inflammation, metabolism, apoptosis, muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. CaM is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. Many of the proteins that CaM binds are unable to bind calcium themselves, and as such use CaM as a calcium sensor and signal transducer. CaM can also make use of the calcium stores in the endoplasmic reticulum, and the sarcoplasmic reticulum. CaM undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response. CaM can bind up to four calcium ions, and can undergo post-translational modifications, such as phosphorylation, acetylation, methylation and proteolytic cleavage, each of which can potentially modulate its actions.
-
HandlingCentrifuge the vial prior to opening.
-
UsageFor Research Use Only! Not to be used in humans
-
Gene target
-
Gene symbolCAMK4
-
Short nameCalmodulin, Brain
-
SpeciesBovine, Bos Taurus genes are available form the Bovine Genome database.
-
Alternative nameCalmodulin, Bovine Brain
-
Tissuebrain
-
Gene info
-
Identity
-
Gene
-
Long gene namecalcium/calmodulin dependent protein kinase IV
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1989-05-24
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Calmodulin dependent protein kinases
-
VEGA ID