BMS-986158

• Catalog number
  B2021-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (S)-2-(3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol
• Description
  BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor.  BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.
• CAS Number
  1800340-40-2 
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₃₃N₅O₂ 
• Molecular Weight
  495.63
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  118196485
• PubChem CID Link
• SMILES
  CC1=C(N(N=N1)C)C2=CC3=C(C4=C(N3C(C5CCOCC5)C6=CC=CC=C6)C=C(C=C4)C(C)(C)O)N=C2
• InChi
  InChI=1S/C30H33N5O2/c1-19-28(34(4)33-32-19)22-16-26-27(31-18-22)24-11-10-23(30(2,3)36)17-25(24)35(26)29(20-8-6-5-7-9-20)21-12-14-37-15-13-21/h5-11,16-18,21,29,36H,12-15H2,1-4H3/t29-/m1/s1
• InChi Key
  KGERZPVQIRYWRK-GDLZYMKVSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BMS-986158  
• Short name
  BMS-986158
• Alternative name
  BMS-986158

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