AT7867

• Catalog number
  B2178-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
• Description
  AT7867 is a potent inhibitor of Akt isoforms Akt1, 2, and 3 (IC₅₀s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC₅₀s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.
• CAS Number
  857531-00-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₂₀ClN₃
• Molecular Weight
  337.9
• Cell Permeable
  Yes
• Purity
  ≥97% by HPLC
• Solubilities
  DMSO (~0.33 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent inhibitor of Akt isoforms Akt1, 2, and 3
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11175137
• PubChem CID Link
• SMILES
  C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl
• InChi
  InChI=1S/C20H20ClN3/c21-19-7-5-18(6-8-19)20(9-11-22-12-10-20)17-3-1-15(2-4-17)16-13-23-24-14-16/h1-8,13-14,22H,9-12H2,(H,23,24)
• InChi Key
  LZMOSYUFVYJEPY-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AT7867  
• Short name
  AT7867
• Alternative name
  AT7867

Similar products