Anti-CD61/ Integrin beta-3 / Platelet Glycoprotein IIIa Antibody (CloneY2/51)

• Catalog number
  A1556-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  CD61
• Target Alternative Name
  BDPLT2; GP3A; GPIIIa; GT; HPA 1; HPA 4; Integrin beta-3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; PTP
• Antibody Type
  Monoclonal
• Clone
  Y2/51
• Species Reactivities
  Human
• Immunogen Sequence
  Phytohemagglutinin (PHA)-stimulated peripheral blood cells
• Accession
  P05106
• Gene Id
  3690
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In 10 mM PBS with 0.05% BSA & 0.05% azide
• Purification
  Protein A/G purification
• Application
  FC, IF, IHC
• Positive Control
  IHC: human Spleen
• Application And Usages
  FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, IHC: 1-2 µg/ml for 30 minutes at RT
• Description
  Reacts with human integrin beta-3 (GPIIIa, vitronectin receptor beta chain). It associates with the V-chain (CD51) to form vitronectin receptor, or with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. Platelets, also called thrombocytes or cloth cells in blood and are needed to stop bleeding by clumping and clotting the blood the vessels when the an injury occurs. Teh bone marrow will produce the platelets that have no nucleus. Platelates are unique to mammals, the are curved shaped 1900nm to 3100 nm large nucleus free clothing structures.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CD61   Integrin   beta-3   Platelet   Glycoprotein   IIIa   CloneY2/51  
• Gene symbol
  ITGB3
• Short name
  Anti-CD61/ Integrin beta-3 / Platelet Glycoprotein IIIa Antibody (CloneY2/51)
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Mouse / IgG1, kappa
• Alternative name
  Antibody toCD61/ Integrin b-3 / Platelet Glycoprotein IIIa (antibody to-) (CloneY2/51)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6156
• Gene
  ITGB3
• Long gene name
  integrin subunit beta 3
• Synonyms gene
  • GP3A
• Synonyms gene name
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
• Synonyms
  • CD61
  • GPIIIa
• Synonyms name
  • platelet glycoprotein IIIa
  • antigen CD61
• Locus
  17q21.32
• Discovery year
  1988-06-09
• Entrez gene record
  3690
• Pubmed identfication
  • 2454952
• RefSeq identity
  • NM_000212
• Classification
  • CD molecules
  • Integrin beta subunits
• VEGA ID
  OTTHUMG00000171956
• Locus Specific Databases
  • LRG_481

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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