Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric)

  • Catalog number
    K897-100
  • Price
    Please ask
  • Size
    100 assays
  • Description
    Highly Sensitive; Includes human ACE2 positive control
  • Summary
    • Detection method - Fluorescence (Ex/Em = 320/420 nm) • Applications- Detection of ACE2 activity in tissue/cell lysates and enzyme preparations
  • Detection Method
    Fluorometric (Ex/Em = 320/420 nm)
  • Species Reactivity
    Mammalian
  • Applications
    Detection of ACE2 activity in tissue/cell lysates and enzyme preparations
  • Sample Type
    • Mammalian tissues: lung, heart, kidney
  • Features Benefits
    • Simple one-step reaction • Takes only 1-2 hrs • Non-radiometric fluorescent detection • HTP adaptable
  • Storage Conditions
    -20°C
  • Shipping Conditions
    gel pack
  • Shelf life
    12 months
  • Background
    Angiotensin II converting enzyme (ACE2, EC 3.4.17.23), a zinc-based metalloprotease, is part of the renin-angiotensin system (RAS) that controls the regulation of blood pressure by cleaving the C-terminal dipeptide of Angiotensin II to convert it into Angiotensin 1-7. ACE2 is a receptor of human coronaviruses, such as SARS and HCoV-NL63. It is expressed on the vascular endothelial cells of lung, kidney and heart. ACE2 is a potential therapeutic target for cardiovascular and coronavirus-induced diseases. BioVision’s ACE2 Activity Assay Kit kit will help the research progress in this field. This kit utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. We also provide an ACE2 specific inhibitor that can differentiate the ACE2 activity from other proteolytic activity.The kit can detect as low as 0.4 mU. Our assay kit is simple and can be used in a high-throughput format
  • Test
    Biovision supplies other types of Assays as 1.
  • Additional description
    Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
  • Gene target
  • Gene symbol
    ACE2
  • Short name
    Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric)
  • Technique
    Enzyme, Assay, assays, enzymes
  • Host
    Assay
  • Alternative name
    Angiotensin II Converting Enzyme (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) Activity test reagent (fluorescence)
  • Alternative technique
    enzymes, arrays, kits
  • Alternative to gene target
    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
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