TIMP 1 (Native Protein)

• Catalog number
  30 111 003
• Price
  Please ask
• Size
  200 µg/ 1 ml

• Protein type
  Native
• Protein subtype
  N/A
• Protein family
  Natural inhibitor of the matrix metalloproteinases
• Protein description
  TIMP1 is a metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
• Research area interests
  Diseases associated with TIMP1 include Chronic Venous Leg Ulcers and Oral Submucous Fibrosis. Among its related pathways are p70S6K Signaling and CREB Pathway
• Package form
  liquid
• Tested applications
  TIMP1 is used to inhibit matrix metalloproteinases
• Other names
  Tissue Inhibitor Of Metalloproteinases 1, Fibroblast Collagenase Inhibitor, Erythroid-Potentiating Activity
• Peptide sequence
  MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA
• Available target modification
  Yes
• Expression system
  human neutrophil granulocytes
• Product Subtype
  full length
• Active form
  No
• Tag
  untagged
• Contents
  50 mM Tris-HCl, pH 7, 200 mM NaCl, 5 mM CaCl2, 1 μM ZnCl2, 0.05%Brij 35, 0.05% NaN3
• Protein purity
  >90%
• Molecular weight
  28 kDa
• UniProt number
  P01033
• Gene number
  7076
• Abbreviation
  TIMP1
• Full name
  TIMP metallopeptidase inhibitor 1
• Other desciption
  The human tissue inhibitor of matrix metalloproteinases TIMP-1 is expressed in Sf9 cells.
• Purification
  Mentioned in the data sheet
• PubMed citations
  See the data sheet
• Warnings
  For Research Use only.
• Shipping conditions
  dry ice
• Storage condition
  Store at -70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
• Other products

• Gene target
  TIMP   Native   Protein  
• Gene symbol
  TIMP1
• Short name
  TIMP 1 (Native Protein)
• Species
  Homo sapiens
• Alternative name
  TIMP 1 (Native Protein)

Gene info

• Identity
  HGNC:11820
• Gene
  TIMP1
• Long gene name
  TIMP metallopeptidase inhibitor 1
• Synonyms gene
  • TIMP
  • CLGI
• Synonyms gene name
  • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
• Synonyms
  • EPO
• Locus
  Xp11.3
• Discovery year
  1986-01-01
• Entrez gene record
  7076
• RefSeq identity
  • NM_003254
• Classification
  • Tissue inhibitor of metallopeptidases
• VEGA ID
  OTTHUMG00000021447
• Locus Specific Databases
  • Global Variome shared LOVD

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