PTPN5/STEP Antibody

• Catalog number
  bs-11328R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PTPN5/STEP Primary Polyclonal Antibody
• Also known as
  PTPN5/STEP PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PTPN5/STEP
• Specificity
  This is a highly specific antibody against PTPN5/STEP.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PTPN5
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The brain-specific STEP (striatal enriched phosphatase) family of protein tyrosine phosphatases (PTPs) comprises both transmembrane and cytosolic protein members which are the products of alternative splicing. STEP family members are expressed in the dopaminoceptive neurons of the CNS, with highest expression in the basal ganglia and related structures. The STEP protein regulates the N-methyl-d-aspartate receptor (NMDAR) complex; STEP depresses both NMDAR single-channel activity and synaptic currents. The membrane-associated STEP61 isoform localizes in the postsynaptic densities (PSDs) of striatal neurons. STEP61 contains a single tyrosine phosphatase domain, two proline-rich domains and two transmembrane domains. The STEP61 protein associates with the Src family kinase member Fyn when Fyn is phosphorylated at Tyr-420 and not Tyr-431. Upon association, STEP61 dephosphorylates Tyr-420 residue and may thus regulate Fyn activity in PSDs. Isolated from mouse brain, the STEP20 isoform lacks the conserved tyrosine phosphatase domain. The human STEP gene maps to chromosome 11p15.2-p15.1.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Neural specic protein tyrosine phosphatase; Neural-specic protein-tyrosine phosphatase; Protein tyrosine phosphatase non receptor type 5 striatum enriched; Protein tyrosine phosphatase non receptor type 5; Protein tyrosine phosphatase striatum enriched; PTN5; PTN5_HUMAN; PTP STEP; PTPN 5; Ptpn5; PTPSTEP; STEP; Striatum-enriched protein-tyrosine phosphatase; Tyrosine protein phosphatase non receptor type 5; Tyrosine-protein phosphatase non-receptor type 5; FLJ14427.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PTPN5  
• Gene symbol
  PTPN5
• Short name
  Anti-PTPN5/STEP
• Technique
  Antibody, step, antibodies against human proteins, antibodies for, steps
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PTPN5/STEP Polyclonal Antibody
• Alternative technique
  antibodies, steps

Gene info

• Identity
  HGNC:9657
• Gene
  PTPN5
• Long gene name
  protein tyrosine phosphatase non-receptor type 5
• Synonyms gene name
  • protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
• Synonyms
  • STEP
  • PTPSTEP
  • STEP61
• Synonyms name
  • striatal-enriched protein tyrosine phosphatase
• GenBank acession
  • BC064807
• Locus
  11p15.1
• Discovery year
  1992-02-12
• Entrez gene record
  84867
• Pubmed identfication
  • 1714595
• RefSeq identity
  • NM_001039970
• Classification
  • Protein tyrosine phosphatases non-receptor type
• VEGA ID
  OTTHUMG00000134304

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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