PARK2(Ser378) Antibody

• Catalog number
  bs-5553R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PARK2(Ser378) Primary Polyclonal Antibody
• Also known as
  PARK2(Ser378) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PARK2 Ser378
• Specificity
  This is a highly specific antibody against PARK2 Ser378.
• Modification s
  Phosphorylation
• Modification site s
  Ser378
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human PARK2 around the phosphorylation site of Ser378
• Gene ID number
  5071
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Parkinson's Disease, the second most common neurodegenerative disease after Alzheimer's Disease, is characterized by the loss of dopaminergic neurons and the presence of Lewy bodies (comprised of alpha synuclein and parkin inclusions). Autosomal Recessive Juvenile Parkinsonism (AR-JP) is a recently described form of Parkinson's Disease that has been linked to a gene that codes for parkin. Parkin, a 52 kDa protein, has a suggested role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  PARK2phospho S378; AR JP; E3 ubiquitin protein ligase parkin; FRA6E; LPRS 2; LPRS2; PARK 2; PARK2; Parkinson disease autosomal recessive juvenile 2; Parkinson disease protein 2; Parkinson juvenile disease protein 2; PDJ; PRKN 2; PRKN; PRKN2; Ubiquitin E3 ligase PRKN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PARK2   Ser378  
• Gene symbol
  PRKN
• Short name
  Anti-PARK2 Ser378
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PARK2(Ser378) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8607
• Gene
  PRKN
• Long gene name
  parkin RBR E3 ubiquitin protein ligase
• Synonyms gene
  • PARK2
• Synonyms gene name
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin)
• Synonyms
  • PDJ
  • AR-JP
  • parkin
• Synonyms name
  • E3 ubiquitin ligase
• Locus
  6q26
• Discovery year
  1997-08-18
• Entrez gene record
  5071
• Pubmed identfication
  • 9560156
  • 9570960
• Classification
  • RBR E3 ubiquitin ligases
• VEGA ID
  OTTHUMG00000015970
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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