UNC5H3/UNC5C Antibody, PE Conjugated
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Catalog number
bs-11493R-PE
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Price
Please ask
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Size
0.1ml
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Long name
UNC5H3/UNC5C Polyclonal Antibody, PE Conjugated
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Category
Conjugated Primary Antibodies
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Conjugation
PE
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
UNC5H3/UNC5C
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Specificity
This is a highly specific antibody against UNC5H3/UNC5C.
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Modification
Unmodified
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Modification site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Subcellular location
Extracellular
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Source
KLH conjugated synthetic peptide derived from human UNC5H3
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Tested applications
FCM
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Recommended dilutions
FCM(1:20-100)
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Crossreactivity
Human, Mouse, Rat
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Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen background
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H3, also known as UNC5C, plays an important role in the development of spinal accessory motor neurons. It is also involved in mediating the repulsive action for netrin-1 and it serves as a stop signal for migratory cells.
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Purification method
This antibody was purified via Protein A.
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Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission
480,565nm/578nm
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Synonyms
Alternative nameshomolog of C. elegans transmembrane receptor Unc5; Netrin receptor UNC5C; Protein unc 5 homolog C; Unc 5 homolog 3; Unc 5 homolog C; Unc5 C.elegans homolog c; UNC5H3; UNC5C_HUMAN.
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Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
UNC5C, UNC5C-AS1
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Short name
Anti-UNC5H3/UNC5C
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Technique
Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
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Isotype
Immunoglobulin G (IgG)
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Label
PE
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Alternative name
Anti-UNC5H3/UNC5C PAb PE
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Alternative technique
antibodies
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Alternative to gene target
unc-5 homolog C (C. elegans), UNC5H3, UNC5C and IDBG-30714 and ENSG00000182168 and 8633, protein binding, Plasma membranes, Unc5c and IDBG-196891 and ENSMUSG00000059921 and 22253, UNC5C and IDBG-640984 and ENSBTAG00000002084 and 533256
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Gene info
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Identity
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Gene
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Long gene name
unc-5 netrin receptor C
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Synonyms gene name
- unc5 (C.elegans homolog) c
- unc-5 homolog C (C. elegans)
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GenBank acession
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Locus
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Discovery year
1998-12-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
UNC5C antisense RNA 1
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Locus
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Discovery year
2020-09-17
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Entrez gene record
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Classification
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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