DC-SIGNR/CD299 Antibody, PE Conjugated

• Catalog number
  bs-10064R-PE
• Price
  Please ask
• Size
  0.1ml

• Long name
  DC-SIGNR/CD299 Polyclonal Antibody, PE Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  PE
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  DC-SIGNR/CD299
• Specificity
  This is a highly specific antibody against DC-SIGNR/CD299.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  KLH conjugated synthetic peptide derived from human CD299
• Gene ID number
  10332
• Tested applications
  FCM
• Recommended dilutions
  FCM(1:20-100)
• Crossreactivity
  Human
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Dendritic cells (DC) play a primary role in the immune system as antigen presenting cells. A key molecule, dendritic cell specific ICAM3 grabbing nonintegrin (DC SIGN1), is involved in regulating interactions between DC and resting T cells, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV 1. Efforts to identify additional type II membrane proteins resulted in the isolation of a related molecule named CD299, also known as DC SIGNR (DC SIGN Related), DC SIGN2, CD209L, and L SIGN (liver/lymph nodespecific ICAM3 grabbing nonintegrin). CD299 is located on Human chromosome 19p13.3 and shares 73-80% amino acid identity with DC SIGN1. Its structure is similar to DC SIGN1 and therefore binds mannose residues in a calcium dependent fashion, including ICAM3 and HIV 1 gp120. CD299 is polymorphic, since allelic variations of the exon 4 encoded sequence have been isolated. This is further supported by a study demonstrating the ability to isolate a large repertoire of CD299 transcripts largely the result of alternative splicing of the 7 coding exons. CD299 is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC. Expression of CD299 is restricted to endothelial cells derived from liver sinusoids, lymph nodes sinuses, and capillaries, although variable expression in placenta and some monocytic cell lines has also been reported, including both membrane and soluble isoforms of the protein.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  480,565nm/578nm
• Synonyms
  C type lectin domain family 4 member M; C type lectin domain family 4, member M; C-type lectin domain family 4, member M; CD209 antigen like protein 1; CD209 antigen-like; CD209L; CD209L1; CD299 antigen; CLEC4M; DC SIGN related protein; DC SIGN2; DC SIGNR; DC-SIGN related protein; DC-SIGN2; DC-SIGNR; DCSIGN-related protein; DCSIGNR; dendritic cell specic ICAM-3-grabbing nonintegrin 2; Dendritic cell-specic ICAM-3-grabbing non-integrin 2; HP10347; L SIGN; Liver/lymph node specic ICAM 3 grabbing nonintegrin; Liver/lymph node-specic ICAM3-grabbing nonintegrin; LSIGN; Mannose binding C-type lectin DC-SIGNR; MGC129964; MGC47866.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DC-SIGNR/CD299   Conjugated  
• Gene symbol
  CLEC4M, CD209, UBTD2, WFDC21P, TSPAN14, DCSTAMP, DCX, LAMP3, PDCD1LG2, CCL18
• Short name
  Anti-DC-SIGNR/CD299
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  PE
• Alternative name
  Anti-DC-SIGNR/CD299 PAb PE
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:13523
• Gene
  CLEC4M
• Long gene name
  C-type lectin domain family 4 member M
• Synonyms gene
  • CD209L
  • CD299
• Synonyms gene name
  • CD299 antigen
  • C-type lectin domain family 4, member M
• Synonyms
  • HP10347
  • DC-SIGNR
  • LSIGN
  • DCSIGNR
  • DC-SIGN2
• GenBank acession
  • AB015629
• Locus
  19p13.2
• Discovery year
  2000-09-19
• Entrez gene record
  10332
• Pubmed identfication
  • 10072769
• RefSeq identity
  • NM_014257
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000182432

Gene info

• Identity
  HGNC:1641
• Gene
  CD209
• Long gene name
  CD209 molecule
• Synonyms gene name
  • CD209 antigen
• Synonyms
  • DC-SIGN
  • hDC-SIGN
  • CDSIGN
  • DC-SIGN1
  • CLEC4L
• GenBank acession
  • M98457
• Locus
  19p13.2
• Discovery year
  2000-07-19
• Entrez gene record
  30835
• Pubmed identfication
  • 1518869
• RefSeq identity
  • NM_021155
• Classification
  • Scavenger receptors
  • C-type lectin domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000182530

Gene info

• Identity
  HGNC:24463
• Gene
  UBTD2
• Long gene name
  ubiquitin domain containing 2
• Synonyms
  • DC-UbP
  • MGC30022
• Synonyms name
  • dendritic cell derived ubiquitin like protein
• GenBank acession
  • AF251700
• Locus
  5q35.1
• Discovery year
  2006-11-06
• Entrez gene record
  92181
• Pubmed identfication
  • 12507522
• RefSeq identity
  • NM_152277
• VEGA ID
  OTTHUMG00000130519

Gene info

• Identity
  HGNC:50357
• Gene
  WFDC21P
• Long gene name
  WAP four-disulfide core domain 21, pseudogene
• Synonyms
  • LOC645638
  • lnc-DC
  • LNCDC
• Synonyms name
  • long non-coding RNA, dendritic cell differentiation
  • WDNM1-like, pseudogene
  • lnc-dendritic cell lncRNA
• Locus
  17q23.1
• Discovery year
  2014-06-16
• Entrez gene record
  645638
• Pubmed identfication
  • 24744378
  • 26158411
• RefSeq identity
  • NR_030732
• VEGA ID
  OTTHUMG00000176074

Gene info

• Identity
  HGNC:23303
• Gene
  TSPAN14
• Long gene name
  tetraspanin 14
• Synonyms gene
  • TM4SF14
• Synonyms gene name
  • transmembrane 4 superfamily member 14
• Synonyms
  • DC-TM4F2
  • MGC11352
• GenBank acession
  • AF311903
• Locus
  10q23.1
• Discovery year
  2004-10-19
• Entrez gene record
  81619
• Pubmed identfication
  • 11230166
• RefSeq identity
  • NM_030927
• Classification
  • Tetraspanins
• VEGA ID
  OTTHUMG00000018615

Gene info

• Identity
  HGNC:18549
• Gene
  DCSTAMP
• Long gene name
  dendrocyte expressed seven transmembrane protein
• Synonyms gene
  • TM7SF4
• Synonyms gene name
  • transmembrane 7 superfamily member 4
• Synonyms
  • DC-STAMP
  • FIND
• Synonyms name
  • Dendritic cells (DC)-specific transmembrane protein
  • IL-Four INDuced
• GenBank acession
  • AF305068
• Locus
  8q22.3
• Discovery year
  2004-06-25
• Entrez gene record
  81501
• Pubmed identfication
  • 11169400
  • 11345591
• RefSeq identity
  • NM_030788
• VEGA ID
  OTTHUMG00000164890

Gene info

• Identity
  HGNC:2714
• Gene
  DCX
• Long gene name
  doublecortin
• Synonyms gene name
  • doublecortex; lissencephaly, X-linked (doublecortin)
• Synonyms
  • SCLH
  • DC
  • LISX
  • DBCN
  • XLIS
• Synonyms name
  • doublecortex
• GenBank acession
  • AF040254
• Locus
  Xq23
• Discovery year
  1998-03-24
• Entrez gene record
  1641
• Pubmed identfication
  • 9489699
  • 9489700
• RefSeq identity
  • NM_178153
• Classification
  • Doublecortin superfamily
• VEGA ID
  OTTHUMG00000022204

Gene info

• Identity
  HGNC:14582
• Gene
  LAMP3
• Long gene name
  lysosomal associated membrane protein 3
• Synonyms gene name
  • lysosomal-associated membrane protein 3
• Synonyms
  • LAMP
  • TSC403
  • DC-LAMP
  • DCLAMP
  • CD208
• GenBank acession
  • AB013924
• Locus
  3q27.1
• Discovery year
  2001-06-29
• Entrez gene record
  27074
• Pubmed identfication
  • 9721848
• Classification
  • Lysosome associated membrane proteins
  • CD molecules
• VEGA ID
  OTTHUMG00000158387

Gene info

• Identity
  HGNC:18731
• Gene
  PDCD1LG2
• Long gene name
  programmed cell death 1 ligand 2
• Synonyms
  • PD-L2
  • Btdc
  • PDL2
  • bA574F11.2
  • CD273
  • B7-DC
• Synonyms name
  • B7 dendritic cell molecule
• GenBank acession
  • AF344424
• Locus
  9p24.1
• Discovery year
  2003-11-14
• Entrez gene record
  80380
• Pubmed identfication
  • 11224527
• RefSeq identity
  • NM_025239
• Classification
  • B7 family
  • CD molecules
  • Immunoglobulin like domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000019504

Gene info

• Identity
  HGNC:10616
• Gene
  CCL18
• Long gene name
  C-C motif chemokine ligand 18
• Synonyms gene
  • SCYA18
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
  • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
  • chemokine (C-C motif) ligand 18
• Synonyms
  • DC-CK1
  • PARC
  • AMAC-1
  • DCCK1
  • MIP-4
  • CKb7
• Synonyms name
  • pulmonary and activation-regulated
• GenBank acession
  • Y13710
• Locus
  17q12
• Discovery year
  1997-01-08
• Entrez gene record
  6362
• Pubmed identfication
  • 9233607
  • 10049593
• RefSeq identity
  • NM_002988
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188410

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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