CDKN1A (Ser146) Antibody, ALEXA FLUOR 350
-
Catalog number
bs-5239R-A350
-
Price
Please ask
-
Size
100ul
-
-
Long name
CDKN1A (Ser146) Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
-
Also known as
Anti-CDKN1A Ser146 PAb ALEXA FLUOR 350
-
Category
Conjugated Primary Antibodies
-
Conjugated with
ALEXA FLUOR® 350
-
Host Organism
Rabbit (Oryctolagus cuniculus)
-
Target Antigen
CDKN1A Ser146
-
Specificity
This is a highly specific antibody against CDKN1A Ser146.
-
Modification
Phosphorylation
-
Modification Site
Ser146
-
Clonality
Polyclonal
-
Clone
Polyclonal antibody
-
Concentration
1ug per 1ul
-
Source
KLH conjugated synthetic phosphopeptide derived from human CDKN1A around the phosphorylation site of Ser146 [QT(p-S)MT]
-
Gene ID Number
1026
-
Tested applications
IF(IHC-P)
-
Recommended dilutions
IF(IHC-P)(1:50-200)
-
Crossreactivity
Human
-
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the antigen
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically.
-
Purification
Purified by Protein A.
-
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
-
Excitation emission
343nm/442nm
-
Synonyms
Activating Fragment 1; CAP20; Cation chloride cotransporter-interacting protein 1; CDK Interacting Protein 1; CDK-interacting protein 1; CDKI; CDKN 1; CDKN1; CDKN1A; CIP1; Cyclin Dependent Kinase Inhibitor 1A; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A P21; Cyclin-dependent kinase inhibitor 1A p21, Cip1; DNA Synthesis Inhibitor; MDA 6; MDA-6; MDA6; Melanoma Dferentiation Associated Protein 6; Melanoma dferentiation-associated protein 6; Melanoma dferentiation-associated protein; p21; P21 protein; p21CIP1; p21WAF; PIC1; SDI1; SLC12A9; WAF1; Wildtype p53 Activating Fragment 1; Wildtype p53-activated fragment 1.
-
Properties
For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
Conjugation
Alexa Fluor, ALEXA FLUOR 350
-
French translation
anticorps
-
Gene target
-
Gene symbol
CDKN1A-AS1, CDKN1A
-
Short name
Anti-CDKN1A Ser146
-
Technique
Antibody, antibodies against human proteins, antibodies for
-
Isotype
Immunoglobulin G (IgG)
-
Label
ALEXA FLUOR 350
-
Alternative name
CDKN1A (Ser146) Polyclonal Antibody, ALEXA FLUOR 350
-
Alternative technique
antibodies
-
Alternative to gene target
cyclin-dependent kinase inhibitor 1A (p21, Cip1), CAP20 and CDKN1 and CIP1 and MDA-6 and P21 and p21CIP1 and SDI1 and WAF1, CDKN1A and IDBG-85033 and ENSG00000124762 and 1026, metal ion binding, nuclei, Cdkn1a and IDBG-159848 and ENSMUSG00000023067 and 12575, CDKN1A and IDBG-630156 and ENSBTAG00000008353 and 513497
-
Gene info
-
Identity
-
Gene
-
Long gene name
CDKN1A antisense RNA 1
-
Synonyms gene name
- CDKN1A antisense RNA 1 (non-protein coding)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
2011-07-11
-
Entrez gene record
-
Pubmed identfication
-
Classification
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products