Adenomatous Polyposis Coli Antibody, ALEXA FLUOR 594

• Catalog number
  bs-3680R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  Adenomatous Polyposis Coli Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-APC/Adenomatous Polyposis Coli PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  APC/Adenomatous Polyposis Coli
• Specificity
  This is a highly specific antibody against APC/Adenomatous Polyposis Coli.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  2790-2843/2843
• Subcellular location
  Cytoplasm
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APC
• Gene ID Number
  324
• Swiss Prot
  P25054
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  GS; DP2; DP3; BTPS2; DP2.5; PPP1R46; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5; APC
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  Adenomatous   Polyposis   Coli  
• Gene symbol
  APC2, MAPRE1, APC
• Short name
  Anti-APC/Adenomatous Polyposis Coli
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Escherichia coli
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  Adenomatous Polyposis Coli Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies, escherichia

Gene info

• Identity
  HGNC:24036
• Gene
  APC2
• Long gene name
  APC regulator of WNT signaling pathway 2
• Synonyms gene name
  • adenomatosis polyposis coli 2
  • APC2, WNT signaling pathway regulator
• Synonyms
  • APCL
• Synonyms name
  • adenomatous polyposis coli like
• Locus
  19p13.3
• Discovery year
  2004-03-18
• Entrez gene record
  10297
• Pubmed identfication
  • 9823329
  • 10021369
• RefSeq identity
  • NM_005883
• Classification
  • Armadillo repeat containing
• VEGA ID
  OTTHUMG00000180059

Gene info

• Identity
  HGNC:6890
• Gene
  MAPRE1
• Long gene name
  microtubule associated protein RP/EB family member 1
• Synonyms
  • EB1
• Synonyms name
  • adenomatous polyposis coli-binding protein EB1
• GenBank acession
  • U24166
• Locus
  20q11.21
• Discovery year
  1999-12-14
• Entrez gene record
  22919
• Pubmed identfication
  • 7606712
  • 9724749
  • 11470413
• RefSeq identity
  • NM_012325
• Classification
  • Microtubule associated protein RP/EB family
• VEGA ID
  OTTHUMG00000032228

Gene info

• Identity
  HGNC:583
• Gene
  APC
• Long gene name
  APC regulator of WNT signaling pathway
• Synonyms gene name
  • adenomatosis polyposis coli
  • adenomatous polyposis coli
  • APC, WNT signaling pathway regulator
• Synonyms
  • DP2
  • DP3
  • DP2.5
  • PPP1R46
• Synonyms name
  • protein phosphatase 1, regulatory subunit 46
• GenBank acession
  • M74088
• Locus
  5q22.2
• Discovery year
  1986-01-01
• Entrez gene record
  324
• Pubmed identfication
  • 1651563
• RefSeq identity
  • NM_000038
• Classification
  • Protein phosphatase 1 regulatory subunits
  • Armadillo repeat containing
• VEGA ID
  OTTHUMG00000128806
• Locus Specific Databases
  • Adenomatous polyposis coli mutation database
  • UMD Locus Specific Databases
  • Global Variome shared LOVD
  • APC database at LOVD-China
  • LOVD - Leiden Open Variation Database
  • LRG_130

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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