AIBAO Chemical

AIBAO Chemical is a professional chemical supplier and R&D company in China, based in Hangzhou near Shanghai, specializing in custom organic synthesis, specialty chemicals, and advanced chemical materials. Supported by RIVER Chemical, the company provides high-quality chemical manufacturing and scalable production solutions, with expertise in amino acid derivatives, peptides, silane products, and lithium battery electrolyte additives. With an experienced technical team and strong research capabilities, AIBAO Chemical delivers custom chemical synthesis services, process optimization, and complex multi-step synthesis solutions, making it a reliable partner for businesses seeking high-performance chemical products and tailored chemical solutions.

Browse AIBAO Chemical Products

(4- fluorophenyl) diphenylsulf onium chloride

SKU: 1261290-16-7|Size: 1 Each

(4-TERT-BUTYL-PHENYL) -PHENYL-AMINE

SKU: 4496-49-5|Size: 1 Each

(4-tert- Butylphenyl) diphenylsulfo nium chloride

SKU: 326925-53-5|Size: 1 Each

(5-Oxotetrahydrofuran-2- yl) methyl methacrylate

SKU: 156938-09-9|Size: 1 Each

1,3,5-Tris[3- (dimethylamino) propyl]hexahydro-1,3,5- triazine

SKU: 15875-13-5|Size: 1 Each

1,3-Dimethyl-1,2,3,4- Tetracalboxylic Dianhydride

SKU: 15894-21-0|Size: 1 Each

1,3-bis (oxiranylmethyl) -5- (2-propenyl) -1,3,5-Triazine- 2,4,6 (1H,3H,5H) -trione

SKU: 69731-45-9|Size: 1 Each

1-Ethylcyclohexyl methacrylate

SKU: 274248-09-8|Size: 1 Each

1-Hydroxycyclohexyl phenyl ketone

SKU: 947-19-3|Size: 1 Each

1-Isopropylcyclopentyl methacrylate

SKU: 1149760-04-2|Size: 1 Each

1-Tetradecylamine

SKU: 2016-42-4|Size: 1 Each

1-isopropylcyclohexyl Methacrylate

SKU: 811440-77-4|Size: 1 Each

11,12-Dihydroindolo[2,3-a]carbazole

SKU: 60511-85-5|Size: 1 Each

12H-Benzofuro[2,3-a]carbazole

SKU: 1338919-70-2|Size: 1 Each

1H,1H-heptafluorobutyl methacrylate

SKU: 13695-31-3|Size: 1 Each

2,2-Dimethoxy-2-phenylacetophenone

SKU: 24650-42-8|Size: 1 Each

2,4-Decadienal

SKU: 2363-88-4|Size: 1 Each

2,4-Diethyl-9H-thioxanthen-9-one

SKU: 82799-44-8|Size: 1 Each

2,5-DIBROMOHYDROQUINONE

SKU: 14753-51-6|Size: 1 Each

2,6,6-trimethylcyclohex-2-ene-1,4-dione

SKU: 1125-21-9|Size: 1 Each

2- (2,4-DIFLUOROPHENYL) PYRIDINE

SKU: 391604-55-0|Size: 1 Each

2- (Methoxymethyl) tricyclo [3.3.1.13,7]dec-2-yl 2- methyl-2-propenoate

SKU: 1154655-97-6|Size: 1 Each

2- (Methylamino) ethanol

SKU: 109-83-1|Size: 1 Each

2- [ (Perfluoropropanoyl) oxy] ethyl methacrylate

SKU: 938459-25-7|Size: 1 Each

2-Bromodiphenylamine

SKU: 61613-22-7|Size: 1 Each

2-Chlorophenyl isocyanate

SKU: 3320-83-0|Size: 1 Each

2-Ethyl-2-adamantyl methacrylate; EAMA

SKU: 209982-56-9|Size: 1 Each

2-Hydroxy-2-methylpropiophenone

SKU: 7473-98-5|Size: 1 Each

2-Hydroxy-4'- (2-hydroxyethoxy) -2-methylpropiophenone

SKU: 106797-53-9|Size: 1 Each

2-Hydroxyethyl Lauryl Amine (2EO)

SKU: 1541-67-9|Size: 1 Each

2-Isopropyl-2-Adamantyl Methacrylate

SKU: 297156-50-4|Size: 1 Each

2-Isopropylthioxanthone

SKU: 5495-84-1|Size: 1 Each

2-Methyl-2-Adamantyl methacrylate

SKU: 177080-67-0|Size: 1 Each

2-Methyl-2-pentenoic acid

SKU: 16957-70-3|Size: 1 Each

2-Methyl-4'- (methylthio) -2-morpholinopropiophenone

SKU: 71868-10-5|Size: 1 Each

2-Methylphenyl isocyanate

SKU: 614-68-6|Size: 1 Each

2-N-Morpholinoethyl methacrylate

SKU: 2997-88-8|Size: 1 Each

2-Oxotetrahydrofuran-3- yl methacrylate

SKU: 195000-66-9|Size: 1 Each

2-Propenoic acid ,2- methyl-,2-ethyldecahydro- 1,4:5,8- dimethanonaphthalen-2-yl este

SKU: 485819-03-2|Size: 1 Each

2-Propenoic acid, 2- methyl-, 1-butoxyethyl ester

SKU: 85997-75-7|Size: 1 Each

2-Propenoic acid, 2- methyl-, 2-[3,3,3-trifluoro- 2-hydroxy-1,1,2- tris (trifluoromethyl) propox y]ethyl ester

SKU: 1263195-13-6|Size: 1 Each

2-Propenoic acid, 2- methyl-, 2-oxo-2-[ (5-oxo- 4- oxatricyclo[4.3.1.13,8]unde c-2-yl) oxy]ethyl este

SKU: 1338917-24-0|Size: 1 Each

2-Propenoic acid, 2- methyl-, 3- (2- hydroxyethoxy) tricyclo[3. 3.1.13,7]dec-1-yl ester

SKU: 862286-54-2|Size: 1 Each

2-Propenoic acid, 2- methyl-, hexahydro-5- oxo-2,6-methanofuro[3,2- b]furan-3-yl ester

SKU: 274248-05-4|Size: 1 Each

2-Propenoic acid, 2-methyl-, cyclobutyl ester

SKU: 118420-89-6|Size: 1 Each

3,3'-Bicarbazole

SKU: 1984-49-2|Size: 1 Each

3,5-DIMETHYLPHENYL ISOCYANATE

SKU: 54132-75-1|Size: 1 Each

3,5-Dichlorophenyl isocyanate

SKU: 34893-92-0|Size: 1 Each

3,6-Dimethyl-9H-carbazole

SKU: 5599-50-8|Size: 1 Each

3- (9H-Carbazole-9-yl) -9H-carbazole

SKU: 18628-07-4|Size: 1 Each

3- (Trifluoromethoxy) phenyl isocyanate

SKU: 55225-86-0|Size: 1 Each

3- (isodecyloxy) propylamine

SKU: 30113-45-2|Size: 1 Each

3-Chloro-4-methylphenyl isocyanate

SKU: 28479-22-3|Size: 1 Each

3-Chlorophenyl isocyanate

SKU: 2909-38-8|Size: 1 Each

3-Dimethylaminopropylamine

SKU: 109-55-7|Size: 1 Each

3-Hydroxy-1-Adamantyl Methacrylate

SKU: 115372-36-6|Size: 1 Each

3-Methoxy propyl amine

SKU: 5332-73-0|Size: 1 Each

3-oxooctahydro-4,7- epoxyisobenzofuran-5-yl methacrylat

SKU: 1258604-98-6|Size: 1 Each

4,4'-Bis (N-carbazolyl) -1,1'-biphenyl

SKU: 58328-31-7|Size: 1 Each

4,4'-Bis (diethylamino) benzophenone

SKU: 90-93-7|Size: 1 Each

4,4,4-Trifluoro-3-hydroxy- 1-Methyl-3- (trifluoroMethyl) butyl -2- Methacrylat

SKU: 630414-85-6|Size: 1 Each

4- (TRIFLUOROMETHYL) PHENYL ISOCYANATE

SKU: 1548-13-6|Size: 1 Each

4- (Trifluoromethoxy) Phenyl Isocyanate

SKU: 35037-73-1|Size: 1 Each

4-Benzoylbiphenyl

SKU: 2128-93-0|Size: 1 Each

4-Bromo-4'-tert-butylbiphenyl

SKU: 162258-89-1|Size: 1 Each

4-Chloro-3-methylphenylisocyanate

SKU: 51488-20-1|Size: 1 Each

4-Isopropylphenyl isocyanate

SKU: 31027-31-3|Size: 1 Each

4-Methylbenzophenone

SKU: 134-84-9|Size: 1 Each

4-[4- (4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl) -phenyl]-dibenzofuran

SKU: 1056113-44-0|Size: 1 Each

5-CHLORO-2-METHYLPHENYL ISOCYANATE

SKU: 40411-27-6|Size: 1 Each

5-Methyl-1H-benzotriazole

SKU: 136-85-6|Size: 1 Each

5-Methyl-2-phenyl-2-hexenal

SKU: 21834-92-4|Size: 1 Each

5-Norbornene-2,3- dicarboximidyl trifluoromethanesulfonate

SKU: 133710-62-0|Size: 1 Each

6-butyl-1,3-dioxo-1H- benzo[de]isoquinolin- 2[3H]-yl-trifluoromethane sulfonate

SKU: 1610827-31-0|Size: 1 Each

9,10-Dibromoanthracene

SKU: 523-27-3|Size: 1 Each

9,10-Diphenylanthracene

SKU: 1499-10-1|Size: 1 Each

9-Anthracenecarboxylic acid, 2- (1,1- dimethylethoxy) -2- oxoethyl este

SKU: 594840-62-7|Size: 1 Each

9-Anthracenylmethyl methacrylate

SKU: 31645-35-9|Size: 1 Each

9-Bromoanthracene

SKU: 1564-64-3|Size: 1 Each

Allyl isothiocyanate

SKU: 57-06-7|Size: 1 Each

Alpha Damascone

SKU: 43052-87-5|Size: 1 Each

Amides, coco, N-[3- (dimethylamino) propyl], N-oxides

SKU: 68155-09-9|Size: 1 Each

Amides, tallow, N-[3- (dimethylamino) propyl], N-oxides

SKU: 68647-77-8|Size: 1 Each

Amines, coco alkyl, ethoxylated (1 - 4.5 moles ethoxylated)

SKU: 61791-14-8|Size: 1 Each

Anise star oil

SKU: 8007-70-3|Size: 1 Each

Anthracene-9-carboxylic acid

SKU: 723-62-6|Size: 1 Each

Benzenamine, 4- (4-dibenzofuranyl) -N-[4- (1-naphthalenyl) phenyl]-

SKU: 2097371-73-6|Size: 1 Each

Benzoic Acid

SKU: 65-85-0|Size: 1 Each

Benzophenone

SKU: 119-61-9|Size: 1 Each

Beta Damascone

SKU: 23726-92-3|Size: 1 Each

Biphenyl-4- fluorophenylsulfoniumtrifl ouromethanesulfonate

SKU: 154093-57-9|Size: 1 Each

Biphenyl-4- methylphenylsulfoniumno naflate

SKU: 880874-07-7|Size: 1 Each

Bis (4- (tert- butyl) phenyl) iodonium

SKU: 229325-98-8|Size: 1 Each

Bis (4-tert- butylphenyl) iodonium perfluoro-1- butanesulfonate

SKU: 194999-85-4|Size: 1 Each

Bis (4-tert- butylphenyl) iodonium trifluoromethanesulfonate

SKU: 84563-54-2|Size: 1 Each

Bis (aminopropyl) laurylamine

SKU: 2372-82-9|Size: 1 Each

Bis (hydrogenated tallow alkyl) methyl

SKU: 61788-63-4|Size: 1 Each

Bis (tert-butylphenyl) Iodonium Chloride

SKU: 5421-53-4|Size: 1 Each

Bourgeonal

SKU: 18127-01-0|Size: 1 Each

Butter acids

SKU: 85536-25-0|Size: 1 Each

Recent Breakthroughs

Design, synthesis, and antidiabetic activity of new furan-clubbed 1,2,3-triazole derivatives as <i>α</i>-glucosidase inhibitors.

Devi P, Maity S, Singh A, Mehan S, Singh G, Asati V.

Future Med Chem

PMID:41994872

Free PMC article

Aim The study aims to design, synthesize, and evaluate novel furan-clubbed 1,2,3-triazole derivatives as potential α-glucosidase inhibitors for the management of diabetes mellitus. Materials and methods Ten furan-clubbed-1,2,3-triazole derivatives PD(1-10) were synthesized and characterized through sophisticated instrumentation techniques, including FT-IR, 1 H NMR, 13 C NMR, and LC-MS. The compounds were assessed in vitro for their ability to inhibit the α-glucosidase enzyme. The in vivo antidiabetic effect of the best molecules was evaluated using STZ-nicotinamide induced diabetic mouse model. The observed results were further supported by molecular docking against α-glucosidase (PDB ID: 3L4U) and histopathological examinations. Results The results of in vitro studies showed that the test compound PD-10 exhibited the strongest α-glucosidase inhibition (IC 5 0 = 13.82 μM), outperforming acarbose (IC 5 0 = 32.03 μM), followed by PD-1 and PD-6 . Further, the in vivo antidiabetic evaluation of the best compounds adjudged compound PD-10 as the best molecule among the series. Docking analyses indicated a significant binding affinity of PD-10 (-4.34 kcal/mol). Conclusions The research highlights PD-10 as a promising α-glucosidase inhibitor with strong in vitro and in vivo antidiabetic effects, supported by favorable molecular docking interactions, and emphasizes its potential for development as an antidiabetic lead for further studies and evaluations.

Mechanistic perspectives on antimalarial agents: from FDA-approved drugs to next-generation candidates.

Monika, Sharma B, Awasthi SK.

RSC Adv

PMID:42006802

Free PMC article

Malaria is a major global health challenge, demanding continued innovation in drug discovery and development. This review gives a comprehensive overview of FDA-approved antimalarial drugs and emerging clinical candidates, focusing their chemical structures, mechanisms of action, and molecular targets such as PfATP4, DHFR, DHODH, and PfCRT. The discussion showcases structure-activity relationships, mechanisms underlying drug resistance, and recent advances in structure-guided design of next-generation antimalarials. The review also summarizes the year of approval, mechanistic class, and synthetic origin of key therapeutic agents. Moreover, novel molecules currently in preclinical and clinical trials are discussed in the context of their mode of action, efficacy, and potential for overcoming resistance. Collectively, this article bridges medicinal chemistry insights with biological mechanisms, outlining future directions in the rational design of potent, resistance-resilient antimalarial drugs.

Total chemical synthesis of pentameric cholera toxin subunit B.

Spaltenstein P, Scherer SR, Jones TE, Giesler RJ, Kay MS.

Chem Commun (Camb)

PMID:41891529

Free PMC article

Vibrio cholerae annually infects millions worldwide, causing intense and life-threatening diarrheal disease. The pentameric cholera toxin subunit B (CtxB) binds to the ganglioside GM1 on epithelial cells, initiating endocytosis and downstream toxicity. We present the total chemical protein synthesis of L-CtxB and mirror-image D-CtxB using a three-segment N-to-C native chemical ligation approach. Oxidative folding produced the desired 62 kDa pentameric proteins, with L-CtxB capable of binding native GM1 ligand. Synthetic D-CtxB is now ready to serve as a target in mirror-image phage display, representing a significant milestone for the discovery of toxin-neutralizing D-peptides to treat and prevent cholera.

Can amoxicillin be detected in the aquatic environment? A critical assessment.

Hernández F, Botero-Coy AM, Bijlsma L, Fabregat-Safont D.

Environ Int

PMID:42001666

Free PMC article

Amoxicillin is a broad-spectrum β-lactam antibiotic widely used in both human and veterinary medicine. Following administration, approximately 60-80% of the dose is excreted, largely unmetabolized, via urine within a few hours. Consequently, environmental contamination with amoxicillin, especially in aquatic systems, is a significant concern. Due to its potential ecological risks and the current scarcity of data required for a full assessment, it was included in two consecutive European Union Watch Lists (2018, 2020) of substances for comprehensive monitoring to inform water policy. However, data on amoxicillin levels in aquatic environments are contradictory, ranging from high concentrations in some studies to non-detection in others. The presence of intact amoxicillin in aquatic environments is inherently transient, and the risk of substantial analytical errors in its detection, identification, and quantification is considerable unless stringent methodological precautions are applied. Driven by the need for reliable environmental data, inconsistencies in the existing literature and our own extensive analytical experience, we comprehensively investigated amoxicillin degradation in surface water, influent and effluent wastewater under various conditions. Experiments were conducted under both dark and sunlight conditions using water samples spiked with amoxicillin at 5 μg/L and 50 μg/L. The parent compound was quantified by liquid chromatography-tandem mass spectrometry, whereas transformation products were identified by high-resolution mass spectrometry. By critically assessing the factors that influence the analysis and environmental occurrence of amoxicillin, this study resolves discrepancies in prior reports and clarifies the realistic prospects for its detection. We demonstrate that the parent antibiotic should be rarely found in water samples due to its rapid degradation. Therefore, future monitoring efforts should be focused on its primary degradation product, amoxicillin penicilloic acid, as more reliable indicator of contamination in aquatic environments.

Characterising the urinary metabolome in HIV/TB coinfection and the impact of antiretroviral treatment.

Allen B, Wood R, Luies L.

BMC Infect Dis

PMID:41992151

Free PMC article

Background HIV/TB coinfection poses significant challenges due to complex interactions between both pathogens and the metabolic disruptions they induce. Although antiretroviral treatment (ART) has transformed disease management, its impact on metabolism is not fully understood. Metabolomics offers an in-depth approach to explore the metabolic changes in this coinfected population, providing information into disease mechanisms and the effects of ART. Methods This exploratory study used untargeted urine gas chromatography mass spectrometry metabolomics to profile metabolic alterations in treatment-naïve HIV/TB coinfected patients and those on ART. Healthy controls were included for comparison. Metabolite changes were analysed using univariate statistical methods, including Kruskal-Wallis tests and pairwise comparisons, to identify key metabolites associated with coinfection and ART. Results Findings revealed significant disruptions in several metabolic pathways. Mitochondrial dysfunction was evident, contributing to altered lipid metabolism, impaired energy production, and increased cardiovascular risk. Disruptions in glucose metabolism, including compromised insulin secretion, were observed, alongside evidence of gut dysbiosis linked to inflammation and microbial imbalance. These metabolic disturbances were also associated with increased oxidative stress, reflected in changes to protein metabolism and the development of cachexia. Although ART partially alleviated some metabolic alterations, disruptions remained evident in treated patients. Conclusion This study provides a comprehensive view of the metabolic disturbances in HIV/TB coinfection and the impact of ART. Our findings suggest that persistent mitochondrial dysfunction, altered lipid metabolism, and gut dysbiosis contribute to ongoing metabolic imbalances, underscoring the need for targeted therapeutic strategies to address these challenges.