FGF2, Basic fibroblast growth factor

  • Catalog number
    IMS01-138-313
  • Price
    Please ask
  • Size
    100 µl (13 mg/ml)
  • Available ordering format
    Liquid in 0.9 % NaCl, 0.1 % sodium azide
  • Immunogen
    purified full length native protein P09038
  • Raised in
    Hen
  • Clonality
    Polyclonal
  • Clone
    Polyclonal
  • Purification
    Total IgY fraction
  • How to reconstitute
    See included datasheet or contact our support service
  • Storage condition
    store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
  • Verified applications
    Western blot (WB)
  • Connected products
    no related to other products
  • Recommended dilutions for use
    1: 1000 with standard ECL (WB), 1: 1000 (ELISA)
  • Molecular weight expected аpparent
    18 kDa
  • Verified reactivity
    human
  • Possible reactivity
    bovine, chicken, mouse, rat, sheep
  • No reactivity
    no confirmed exceptions from predicted reactivity known in the moment
  • Supplementary information
    reacts with human recombinant FGF2. No reactivity with other human serum proteins
  • References
    to be added when available
  • Scientific context
    Basic Fibroblast Growth Factor (FGF2) is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. FGF2 is involved in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. FGF2 mRNA contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
  • Notes
    the IgY fraction is isolated by a two-step PEG precipitation procedure followed by ammonium sulphate precipitation
  • Protein number
    P09038
  • TAIR number
    Refer to NCBI
  • Description
    Basic proteins pH>7 are often produced recombinant and shouldn’t be precipitated by formic acid buffer. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
  • Gene target
  • Gene symbol
    FGF2, FGF13
  • Short name
    FGF2, fibroblast growth factor
  • Alternative name
    fibroblast growth factor 2 (basic), Basic fibroblast growth factor
  • Alternative to gene target
    fibroblast growth factor 2 (basic), BFGF and FGF-2 and FGFB and HBGF-2, FGF2 and IDBG-37039 and ENSG00000138685 and 2247, chemoattractant activity, nuclei, Fgf2 and IDBG-140464 and ENSMUSG00000037225 and 14173, BT.66957 and IDBG-630303 and ENSBTAG00000005691 and 281161
Gene info
  • Identity
  • Gene
  • Long gene name
    fibroblast growth factor 2
  • Synonyms gene
  • Synonyms gene name
    • fibroblast growth factor 2 (basic)
  • GenBank acession
  • Locus
  • Discovery year
    1986-01-01
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Fibroblast growth factor family
    • Receptor ligands
  • VEGA ID
  • Locus Specific Databases
Gene info
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