AMBP, Alpha-1-microglobulin
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Catalog numberAS01 014
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PricePlease ask
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Size200 µl
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Available ordering formatLyophilized with 0.04% sodium azide
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Immunogenrat alpha-1-microglobulin, full length, recombinant protein, overexpressed in baculovirus-infected insect cells with N-terminal His-tag
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Raised inRabbit
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ClonalityPolyclonal
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ClonePolyclonal
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PurificationSerum
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How to reconstituteFor reconstitution add 200 µl of sterile water
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Storage conditionstore lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
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Verified applicationsWestern blot (WB), radioimmunoassay (RIA), immunocytochemistry (ICC)
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Connected productsAS01 013 | alpha-1-microglobulin (abcam BN11.10), mouse monoclonal antibodyAS13 2670 | A1M | human alpha-1-microglobulin, chicken antibodyAS10 1354 | B2M | beta-2-microglobulin, goat antibodySecondary antibodies
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Recommended dilutions for use1: 2000 (WB), 1: 6000 (RIA), 1: 5000 (ELISA), 1: 200 (IHC)
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Molecular weight expected аpparent27 kDa
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Verified reactivityrat
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Possible reactivitymouse
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No reactivityno confirmed exceptions from predicted reactivity known in the moment
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Supplementary informationContact Gentaur support center at [email protected]
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ReferencesSanchez et al. (2002) Expression of the AMBP gene transcript and its two protein products, alpha(1)-microglobulin and bikunin, in mouse embryogenesis. Mech Dev, 117:293-8.Ostendorf et al. (2006) Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis. J Am Soc Nephrol, 17:1054-62.
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Scientific contextAlpha-1-microglobulin is a 27-kDa glycoprotein with immunosuppressive properties. A gene AMBP in the lipocalin cluster encodes alpha-1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha-1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins are secreted to the blood separately. Alpha-1-microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha 1-microglobulin is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function.
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NotesNone
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Protein numberRefer to NCBI
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TAIR numberRefer to NCBI
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DescriptionThe AMBP, Alpha-1-microglobulin is a α- or alpha protein sometimes glycoprotein present in blood.
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Gene target
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Gene symbolAMBP, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1, MIR16-1
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Short nameAMBP, Alpha-1-microglobulin
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Alternative namealpha-1-microglobulin/bikunin precursor, a-1-microglobulin
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Alternative to gene targetalpha-1-microglobulin/bikunin precursor, A1M and EDC1 and HCP and HI30 and IATIL and ITI and ITIL and ITILC and UTI, AMBP and IDBG-81952 and ENSG00000106927 and 259, calcium oxalate binding, Extracellular, Ambp and IDBG-154074 and ENSMUSG00000028356 and 11699, AMBP and IDBG-638444 and ENSBTAG00000015676 and 280996
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Gene info
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Identity
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Gene
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Long gene namealpha-1-microglobulin/bikunin precursor
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Lipocalins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable (II)-1-1 (pseudogene)
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Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1-1
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1/206 family
Gene info
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Identity
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Gene
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Long gene nametRNA-undetermined (NNN) 8-1
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Synonyms gene name
- transfer RNA-undetermined (NNN) 8-1
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GenBank acession
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Locus
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Discovery year2014-06-20
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Entrez gene record
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Pubmed identfication
Gene info
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Identity
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Gene
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Long gene nametRNA-undetermined (NNN) 7-1
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Synonyms gene name
- transfer RNA-undetermined (NNN) 7-1
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GenBank acession
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Locus
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Discovery year2014-06-20
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Entrez gene record
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Pubmed identfication
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 1/OR2-1 (pseudogene)
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Synonyms gene
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Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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Pubmed identfication
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Classification
- Immunoglobulin kappa (IGK) orphons
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 101-1
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR101 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1289-1
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1289 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 16-1
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR15/16 family