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YK 4 279 for cell activation

YK 4 279 for cell activation is available 2 times from Biovision labs

2846-5 | YK-4-279 for cell activation size: 5 mg | 172.97 USD

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2846-25 | YK-4-279 for cell activation size: 25 mg | 517.77 USD

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Other name  4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
Supplied with N/A
Description YK-4-279 is an Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC₅₀ values ranging from 0.5-2 µM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.
Category Biochemicals
Molecular formula C₁₇H₁₃Cl₂NO₄
Is it cell-permeable? Yes
Molecular weight 366.2
Storage condition -20°C
Shipping condition gel pack
Purification ≥98% by HPLC
Peptide sequence N/A
Is this a salt? No
CAS number 1037184-44-3
Storage instructions Protect from air and light
Maximum time for storage 36 months
Physical appearance White solid
Reconstitute instructions DMSO (>30 mg/ml)
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetYK-4-279 for activation
Short name YK-4-279 for activation
Technique activation
Alternative name YK-4-279 to measure cellular activation
Tissue cell
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