Recombinant Mouse Prostasin / PRSS8 Protein (aa 30-289, His tag) 20µg

• Catalog number
  PKSM040855-20µg
• Price
  Please ask
• Size
  20µg

• Activity
  NA
• Synonym
  2410039E18Rik;AI313909;C79772;CAP1;fr;mCAP1
• Sequence
  Ala 30-Gln 289
• Fusion tag
  C-His
• Accession
  EDL17608.1 
• Expressed Host
  Baculovirus-Insect Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 97 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  29.3 kDa
• AP Mol Mass
  35 kDa
• Formulation
  Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4
• Background
  Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Prostasin   PRSS8   Protein   30-289   His   tag   20µg  
• Gene symbol
  PRSS8, SNORD89, SNORD114-30, SNORD116-30, SNORD115-30, IGKV2-30, RNU6-30P, IGHV3-30, IGLV3-30, IGHVII-30-21
• Short name
  Recombinant Mouse Prostasin / PRSS8 Protein (aa 30-289, His tag) 20µg
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse Prostasin / PRSS8 Protein (aa 30-289, histidine detection labelled) 20µg
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:9491
• Gene
  PRSS8
• Long gene name
  serine protease 8
• Synonyms gene name
  • protease, serine 8
• Synonyms
  • CAP1
• Synonyms name
  • prostasin
  • channel-activating serine protease 1
• GenBank acession
  • U33446
• Locus
  16p11.2
• Discovery year
  1995-10-17
• Entrez gene record
  5652
• Pubmed identfication
  • 8838796
  • 7768952
• RefSeq identity
  • NM_002773
• Classification
  • Serine proteases
• VEGA ID
  OTTHUMG00000176750

Gene info

• Identity
  HGNC:32750
• Gene
  SNORD89
• Long gene name
  small nucleolar RNA, C/D box 89
• Synonyms
  • HBII-289
• Locus
  2q11.2
• Discovery year
  2006-05-08
• Entrez gene record
  692205
• Pubmed identfication
  • 11387227
• RefSeq identity
  • NR_003070
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33018
• Gene
  SNORD114-30
• Long gene name
  small nucleolar RNA, C/D box 114-30
• Synonyms
  • 14q(II-30)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767611
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003223.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:42797
• Gene
  SNORD116-30
• Long gene name
  small nucleolar RNA, C/D box 116-30
• Synonyms
  • HBII-85-30
• Locus
  15q11.2
• Discovery year
  2011-08-22
• Entrez gene record
  100873856
• RefSeq identity
  • NR_047032
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33049
• Gene
  SNORD115-30
• Long gene name
  small nucleolar RNA, C/D box 115-30
• Synonyms
  • HBII-52-30
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033804
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003345.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5785
• Gene
  IGKV2-30
• Long gene name
  immunoglobulin kappa variable 2-30
• GenBank acession
  • X63403
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28919
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151692

Gene info

• Identity
  HGNC:34274
• Gene
  RNU6-30P
• Long gene name
  RNA, U6 small nuclear 30, pseudogene
• Synonyms gene
  • RNU6-30
• Synonyms gene name
  • RNA, U6 small nuclear 30
• Locus
  Xq22.1
• Discovery year
  2008-06-10
• Entrez gene record
  100873747
• RefSeq identity
  • NR_046490

Gene info

• Identity
  HGNC:5591
• Gene
  IGHV3-30
• Long gene name
  immunoglobulin heavy variable 3-30
• GenBank acession
  • M83134
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28439
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000188332

Gene info

• Identity
  HGNC:5912
• Gene
  IGLV3-30
• Long gene name
  immunoglobulin lambda variable 3-30 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable 3-30
  • immunoglobulin lambda variable 3-30 pseudogene
• GenBank acession
  • Z73646
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28789
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151182

Gene info

• Identity
  HGNC:52400
• Gene
  IGHVII-30-21
• Long gene name
  immunoglobulin heavy variable (II)-30-21 (pseudogene)
• Synonyms
  • IGHV(II)-30-21
• Locus
  14q32.33
• Discovery year
  2016-11-10
• Entrez gene record
  107548099
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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