AQP4 Antibody Aquaporin 4

• Catalog number
  R30323
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  AQP4 Aquaporin 4
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting points. Titration of the AQP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This AQP4 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P55087
• Purity
  Antigen affinity
• Description
  Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells. The gene is mapped to 18q11.2-q12.1. Similar to other aquaporins, the AQP4 gene is composed of 4 exons encoding 127, 55, 27, and 92 amino acids separated by introns of 0.8, 0.3, and 5.2 kb. Unlike other aquaporins, an alternative coding initiation sequence(designated exon 0) was located 2.7 kb upstream of exon 1. When spliced together, M1 and the subsequent 10 amino acids are encoded by exon 0; the next 11 amino acids and M23 are encoded by exon 1. The protein is expressed in astrocytes and is upregulated by direct insult to the central nervous system. AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis. It is abundant in mammalian brain and is concentrated in astrocytic foot processes at the blood-brain barrier.
• Immunogen
  An amino acid sequence from the C-terminus of human Aquaporin 4 (FTIFASCDSKRTDVTGS) was used as the immunogen for this AQP4 antibody.
• Storage
  After reconstitution, the AQP4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  AQP4   Aquaporin  
• Gene symbol
  AQP4, AQP4-AS1
• Short name
  Anti-AQP4 Aquaporin 4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to AQP4 Aquaporin 4
• Alternative technique
  antibodies
• Alternative to gene target
  aquaporin 4, HMIWC2 and MIWC, AQP4 and IDBG-1836 and ENSG00000171885 and 361, porin activity, Cell surfaces, Aqp4 and IDBG-129483 and ENSMUSG00000024411 and 11829, AQP4 and IDBG-643803 and ENSBTAG00000019037 and 281008

Gene info

• Identity
  HGNC:637
• Gene
  AQP4
• Long gene name
  aquaporin 4
• Synonyms
  • MIWC
• GenBank acession
  • U63622
• Locus
  18q11.2
• Discovery year
  1994-07-25
• Entrez gene record
  361
• Pubmed identfication
  • 7528931
• RefSeq identity
  • NM_001650
  • NM_004028
• Classification
  • Aquaporins
• VEGA ID
  OTTHUMG00000131955

Gene info

• Identity
  HGNC:26399
• Gene
  AQP4-AS1
• Long gene name
  AQP4 antisense RNA 1
• Synonyms gene
  • C18orf16
  • CHST9-AS1
• Synonyms gene name
  • chromosome 18 open reading frame 16
  • CHST9 antisense RNA 1
• Synonyms
  • FLJ30507
• GenBank acession
  • AK055069
• Locus
  18q11.2
• Discovery year
  2004-04-30
• Entrez gene record
  147429
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000131954

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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