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Human CellExp IL-1 Human recombinant

Human CellExp IL-1 Human recombinant is available 10 times from Biovision labs

7275-10 | Human CellExp IL-1 Alpha, human recombinant size: 10 μg | 530.53 USD

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P1019-10 | Human CellExp IL-1 beta / IL-1F2, Human recombinant size: 10 µg | 411.31 USD

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P1019-25 | Human CellExp IL-1 beta / IL-1F2, Human recombinant size: 25 µg | 625.91 USD

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7392-10 | Human CellExp IL-1 RII /CD121b, human recombinant size: 10 μg | 393.43 USD

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7392-50 | Human CellExp IL-1 RII /CD121b, human recombinant size: 50 μg | 888.19 USD

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7275-10 | Human CellExp™ IL-1 Alpha, human recombinant size: 10 μg | 442.31 USD

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P1019-10 | Human CellExp™ IL-1 beta / IL-1F2, Human recombinant size: 10 µg | 312.36 USD

Catalog number P1019-10
Supplier Biovision
Price 312.36 USD
Size 10 µg
Target IL1B
Background Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta. IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Molecular weight The protein has a calculated MW of 17.5 kDa. The predicted N-terminus is Met. The reducing protein migrates as 18 kDa in SDS-PAGE.
Synonym IL1B, IL-1BETA, IL1F2, IL-1β, Catabolin
Other name IL1B, IL-1BETA, IL1F2, IL-1β, Catabolin
NCBI gene number 3553
NCBI gene IL1B
NCBI number P01584
Source HEK 293 cells
Purification ≥ 97%
Level of endotoxin< 1 EU/μg
Tested activity Prolifiration assay
Biological activity The bio-activity was determined by dose-dependent stimulation of the proliferation of mouse D10.G4.1 cells. The ED50 < 2 pg/mL, corresponding to a specific activity of >500,000,000 Unit/mg.
Reesults >500,000,000 Unit/mg.
Shipping under Gel pack
Physical appearance Lyophilized
Physical properties Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
How to reconstitute Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Gene The Interleukin-1 family (IL-1 family) is a group of 11 cytokines, which plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Rec. E. coli interleukin-1 for cell culture or antibody production.
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetCellExp™ IL-1 beta IL-1F2
Short name CellExp™ IL-1 beta / IL-1F2, recombinant
Species Humans
Alternative name H. sapiens CellExp™ Interleukin-1 b / Interleukin-1F2, H. sapiens recombinant
1. Gene info
Identity 13765
Gene IL25
Long gene name interleukin 25
Synonyms gene
  • IL17E
Synonyms gene name
  • interleukin 17E
Synonyms
  • IL-25
  • IL-17E
GenBank acession
  • AF305200
Locus 14q11.2
Discovery year 2001-01-26
Pubmed identfication
  • 11058597
  • 11754819
Classification
  • Interleukins
Havana BLAST/BLAT OTTHUMG00000028749
2. Gene info
Identity 5992
Gene IL1B
Long gene name interleukin 1 beta
Synonyms
  • IL1F2
  • IL-1B
  • IL1-BETA
GenBank acession
  • M15330
Locus 2q14.1
Discovery year 1989-03-31
Entrez gene record 3553
Pubmed identfication
  • 2954882
  • 2989698
RefSeq identity
  • NM_000576
Classification
  • Interleukins
Havana BLAST/BLAT OTTHUMG00000131344
3. Gene info
Identity 5990
Gene IL19
Long gene name interleukin 19
Synonyms
  • IL-19
  • MDA1
  • ZMDA1
  • IL-10C
  • NG.1
Synonyms name
  • melanoma differentiation associated protein-like protein
GenBank acession
  • AF192498
Locus 1q32.1
Discovery year 2000-03-29
Entrez gene record 29949
Pubmed identfication
  • 11196675
RefSeq identity
  • NM_153758
Classification
  • Interleukins
Havana BLAST/BLAT OTTHUMG00000036387
4. Gene info
Identity 5991
Gene IL1A
Long gene name interleukin 1 alpha
Synonyms gene
  • IL1
Synonyms
  • IL1F1
  • IL-1A
  • IL1-ALPHA
Synonyms name
  • preinterleukin 1 alpha
  • hematopoietin-1
  • pro-interleukin-1-alpha
GenBank acession
  • M28983
Locus 2q14.1
Discovery year 2001-06-22
Entrez gene record 3552
Pubmed identfication
  • 8188271
  • 2989698
RefSeq identity
  • NM_000575
Classification
  • Interleukins
Havana BLAST/BLAT OTTHUMG00000131315
Product images
    #Human#.jpg#0#.jpegHuman CellExp™ IL-1 beta / IL-1F2, Human recombinant

P1019-25 | Human CellExp™ IL-1 beta / IL-1F2, Human recombinant size: 25 µg | 546.03 USD

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7392-10 | Human CellExp™ IL-1 RII /CD121b, human recombinant size: 10 μg | 293.28 USD

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7392-50 | Human CellExp™ IL-1 RII /CD121b, human recombinant size: 50 μg | 830.96 USD

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Concentration N/A
Gene source Human
Recombinant Yes
Tested applications SDS-PAGE, N/A
Binding ability N/A
Unit N/A
Storage condition -20°C
Aa sequence N/A
Before use Centrifuge the vial prior to opening.
Notes For Research Use Only! Not to be used in humans
Gene Source Human
Purity N/A
Storage Temp. -20°C
Shelf Life 1 year
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Technique Recombinant
Alternative technique rec
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CellExp™ IL-1 beta / IL-1F2, recombinant | Technique alterna
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  • CellExp
  • IL-1
  • Alpha
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