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Gene info
ERK2, a MAPK type protein kinase, is a member of the Ras MAPK pathway. This pathway modulates the activity of transcription factors, structural proteins and other protein kinases, leading to biological responses such as cell proliferation and differentiation. Inactive ERK2 associates with MAPK/ERK kinases (MEK) 1 and 2 in the cytosol. Upon stimulation, MEK1/2 phosphorylates and activates ERK2 causing dissociation of the MEK/ERK complex. A portion of the activated ERK2 pool forms dimers and translocates to the nucleus to activate nuclear proteins, such as ELK-1 and MSK1. Cytosolic ERK 2 acts on a different set of substrates, including MNK1/2 and MAPKAP-K1.
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Gene names
MAPK1, ERK, ERK-2, ERK2, MAP kinase 1, MAPK 2, MAPK2, MAP kinase isoform p42, MAPK 1, p41mapk, PRKM2, MAP kinase 2, p41, p42-MAPK, PRKM1, ERT1, p38, p40, p42MAPK, Protein tyrosine kinase ERK2
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Antibodie s label
unlabelled serum
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Purity
Affinity Chromatography
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Ab raised in
Mouse
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Type
Monoclonal
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Monoclonal
[4C11C11C4]
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Immunoglobulin
IgG2a
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Antigen
MAPK1 monoclonal antibody was made against Ni-NTA purified full length recombinant ERK2 expressed in E. coli strain BL21 (DE3).
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Immuno application
ELISA, Western Blot, immuno-histo-chemistry
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Antibody advice
MAPK1 antibody can be used in Western Blot starting at 1:500 - 1:3000, immunohistochemistry starting at 1:400, immunoprecipitation, and immunofluorescence.
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Suspention pH azide
PBS, 0.01% sodium azide.
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Keep at
Store MAPK1 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works with
Human
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Omim nr
119554
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Ncbi nr
P28482
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Vial with antibody
in solution
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NCBI GENE nr
5594
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GENE symbol
MAPK1
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Antigene name
mitogen-activated protein kinase 1
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Source
Homo sapiens
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Protein nr
P28482
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
MAPK1
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Short name
anti-MAPK1 Antibody [4C11C11C4]
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toMAPK1 (antibody to-) [4C11C11C4]
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Alternative technique
antibodies
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Alternative to gene target
mitogen-activated protein kinase 1, ERK and ERK-2 and ERK2 and ERT1 and MAPK2 and p38 and p40 and p41 and p41mapk and p42-MAPK and P42MAPK and PRKM1 and PRKM2, MAPK1 and IDBG-2147 and ENSG00000100030 and 5594, transferase activity, nuclei, Mapk1 and IDBG-137672 and ENSMUSG00000063358 and 26413, MAPK1 and IDBG-637539 and ENSBTAG00000010312 and 327672
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