c-Abl Antibody (ABL1)

• Catalog number
  F50695-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  c-Abl (ABL1)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the ABL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ABL1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P00519
• Purity
  Antigen affinity
• Description
  The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
• Immunogen
  A portion of amino acids 231-260 from the human protein was used as the immunogen for this ABL1 antibody.
• Storage
  Aliquot the ABL1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  c-Abl   ABL1  
• Gene symbol
  ABL1
• Short name
  Anti-c-Abl (ABL1)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to c-Abl (ABL1)
• Alternative technique
  antibodies
• Alternative to gene target
  c-abl oncogene 1, non-receptor tyrosine kinase, ABL and bcr/abl and c-ABL and c-ABL1 and JTK7 and p150 and v-abl, ABL1 and IDBG-89599 and ENSG00000097007 and 25, transferase activity, nuclei, Abl1 and IDBG-158216 and ENSMUSG00000026842 and 11350, ABL1 and IDBG-639939 and ENSBTAG00000017976 and 540876

Gene info

• Identity
  HGNC:76
• Gene
  ABL1
• Long gene name
  ABL proto-oncogene 1, non-receptor tyrosine kinase
• Synonyms gene
  • ABL
• Synonyms gene name
  • v-abl Abelson murine leukemia viral oncogene homolog 1
  • c-abl oncogene 1, receptor tyrosine kinase
  • c-abl oncogene 1, non-receptor tyrosine kinase
• Synonyms
  • JTK7
  • c-ABL
  • p150
• GenBank acession
  • M14752
• Locus
  9q34.12
• Discovery year
  1986-01-01
• Entrez gene record
  25
• Pubmed identfication
  • 1857987
  • 12626632
• RefSeq identity
  • NM_007313
• Classification
  • Abl family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000020813
• Locus Specific Databases
  • LRG_769

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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