BAZ2-ICR

• Catalog number
  B1865-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile; BAZ2ICR
• Description
  BAZ2-ICR is a small molecule inhibitor of BAZ2A (Kd = 109 nM; IC₅₀ = 130 nM) and BAZ2B (Kd = 170 nM; IC50 = 180 nM) bromodomains. It displays 15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR has been shown to displace BAZ2 bromodomains in living cells by demonstrating accelerated FRAP recovery at 1 µM in the BAZ2A FRAP assay.
• CAS Number
  1665195-94-7
• Structure Available
  Yes
• Molecular Formula
  C₂₀H₁₉N₇
• Molecular Weight
  357.41
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A bromodomain inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  91654625
• PubChem CID Link
• SMILES
  CN1C=C(C=N1)CCN2C=NC(=C2C3=CC=C(C=C3)C#N)C4=CN(N=C4)C
• InChi
  InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3
• InChi Key
  RRZVGDGTWNQAPW-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BAZ2-ICR  
• Short name
  BAZ2-ICR
• Alternative name
  BAZ2-ICR

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