IGF-BP1, human recombinant
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Catalog number4717-25
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PricePlease ask
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Size25 ug
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SynonymsIBP-1, IGF-Binding Protein 1, AFBP, PP12, IGF-BP25, hIGFBP-1, IGFBP-1.
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Alternative_namesIBP-1, IGF-Binding Protein 1, AFBP, PP12, IGF-BP25, hIGFBP-1, IGFBP-1.
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DescriptionA protein which binds and prolongs the half-life of the IGFs
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RecombinantYes
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SourceNso cells
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Purity by SDS PAGE≥98%
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AssaySDS-PAGE
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Purity≥98%
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Biological activityThe ED₅₀ as determined by its ability to inhibit IGF-I induced proliferation of NUC-1 cells is ~100 ng/ml.
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Results~100 ng/ml
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Molecular Weight28.8 kDa
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Storage Temp-20°C
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ShippingGel pack
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Shelf Life12 months
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AppearanceLyophilized protein
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Physical form descriptionSterile filtered and lyophilized from 10 mM HCl.
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Reconstitution InstructionsReconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
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Background InformationHuman IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, decidual, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, whereas nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a single, glycosylated protein consisting of 218 amino acid residues.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional descriptionIGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolSIGMAR1, EIF4EBP1, REXO1, DLX4, GORAB, ATF2, NAE1, TSPOAP1, SIGLEC6
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Short nameIGF-BP1, recombinant
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TechniqueRecombinant, IGF, igfs, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameIGF-BP1, H. sapiens Rec.
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Alternative techniquerec, igfs
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Gene info
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Identity
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Gene
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Long gene namesigma non-opioid intracellular receptor 1
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Synonyms gene
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Synonyms gene name
- opioid receptor, sigma 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-03-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameeukaryotic translation initiation factor 4E binding protein 1
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Synonyms
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Synonyms name
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Locus
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Discovery year1996-10-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNA exonuclease 1 homolog
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Synonyms gene
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Synonyms gene name
- transcription elongation factor B polypeptide 3 binding protein 1
- REX1, RNA exonuclease 1 homolog (S. cerevisiae)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-01-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
- Exonucleases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namedistal-less homeobox 4
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Synonyms gene
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Synonyms
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Locus
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Discovery year1996-08-07
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Entrez gene record
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Classification
- NKL subclass homeoboxes and pseudogenes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegolgin, RAB6 interacting
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Synonyms gene
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Synonyms gene name
- SCY1-like 1 binding protein 1
- golgin, RAB6-interacting
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-05-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameactivating transcription factor 2
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Synonyms gene
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Synonyms gene name
- cAMP responsive element binding protein 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-08-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Basic leucine zipper proteins
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNEDD8 activating enzyme E1 subunit 1
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Synonyms gene
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Synonyms gene name
- amyloid beta precursor protein binding protein 1, 59kDa
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-01-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ubiquitin like modifier activating enzymes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTSPO associated protein 1
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Synonyms gene
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Synonyms gene name
- benzodiazepine receptor (peripheral) associated protein 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-03-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fibronectin type III domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesialic acid binding Ig like lectin 6
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Synonyms gene
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Synonyms gene name
- sialic acid binding Ig-like lectin 6
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-12-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- I-set domain containing
- Sialic acid binding Ig like lectins
- V-set domain containing
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data