Recombinant Human ADSL / Adenylosuccinate Lyase Protein (His tag) 100µg

• Catalog number
  PKSH031168-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  AMPS;ASASE;ASL
• Activity
  NA
• Sequence
  Met 1-Leu 484
• Fusion tag
  N-His
• Accession
  P30566-1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  57 kDa
• AP Mol Mass
  53 kDa
• Formulation
  Lyophilized from sterile PBS, 10% glycerol, pH 7.5
• Reconstitution
  Please refer to it for detailed information.
• Background
  Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotides, both of which involve the _-elimination of fumarate to produce either aminoimidazole carboxamide ribotide from SAICAR or AMP from S-AMP. The Adenylosuccinate lyase deficiency is a rare autosomal recessive metabolic disorder characterized by the present of SAICA riboside and succinyladenosine (S-Ado). ADSL defect in different patients is often caused by different mutations to the enzyme.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ADSL   Adenylosuccinate   Lyase   Protein   His   tag   100µg  
• Gene symbol
  ADSL
• Short name
  Recombinant ADSL / Adenylosuccinate Lyase Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens ADSL / Adenylosuccinate Lyase Protein (histidine detection labelled) 100µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:291
• Gene
  ADSL
• Long gene name
  adenylosuccinate lyase
• GenBank acession
  • X65867
• Locus
  22q13.1
• Discovery year
  1986-01-01
• Entrez gene record
  158
• Pubmed identfication
  • 8404037
• RefSeq identity
  • NM_000026
• Classification
  • Purinosome
• VEGA ID
  OTTHUMG00000166425
• Locus Specific Databases
  • Adenylosuccinate Lyase Mutations Database Home Page

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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