AG-014699 phosphate
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Catalog number2890-1
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PricePlease ask
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Size1 mg
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Alternative_name8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate; Rucaparib; PF-01367338
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DescriptionAG-014699 phosphate is a potent, cell-permeable inhibitor of PARP1 with Ki of 1.4 nM. It selectively binds to PARP 1 and inhibits the PARP1-mediated DNA repair, thus potentiating the genomic instability and apoptosis. Displays antineoplastic activity.
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CAS Number459868-92-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₉H₂₁FN₃O₅P
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Molecular Weight421.36
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Cell Permeableyes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~20 mg/ml)
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HandlingProtect from air and moisture
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Tag LineA potent PARP1 inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID9931953
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SMILESCNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O
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InChiInChI=1S/C19H18FN3O.H3O4P/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-5(2,3)4/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);(H3,1,2,3,4)
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InChi KeyFCCGJTKEKXUBFZ-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolTPBG, BCAP31
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Short nameAG-014699 phosphate
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Alternative nameAG-014699 phosphate
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Gene info
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Identity
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Gene
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Long gene nametrophoblast glycoprotein
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-10-16
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameB cell receptor associated protein 31
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-12-22
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Entrez gene record
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RefSeq identity
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VEGA ID